Navegando por Palavras-chave "Vitamin B 12 Deficiency"

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    Associação entre o uso prolongado de omeprazol e a deficiência de vitamina B12, ferro e magnésio em indivíduos muito idosos independentes
    (Universidade Federal de São Paulo (UNIFESP), 2021) Didone, Thiago Vinicius Nadaleto [UNIFESP]; Shinohara, Elvira Maria Guerra [UNIFESP]; Universidade Federal de São Paulo
    The aim of this study was to investigate the association between long-term use of omeprazole and magnesium, vitamin B12 and iron deficiency. Therefore, people aged ≥80 years and functionally independent, participating in the Longevous Project (Discipline of Geriatrics and Gerontology, EPM/UNIFESP), were followed retrospectively for 2 years. Users of stomach acid suppressants, other than omeprazole, and dietary supplements containing the micronutrients of interest, and those with hematological diseases and health conditions that may interfere with the absorption of these micronutrients, were excluded. We obtained primary data, from serum aliquots, and secondary data, from medical record, at baseline (T0) and after 1 (T1) and 2 (T2) years of follow-up. Information on the use of medications was self-reported. The individuals were divided between users (OMP group) and non-users (CTR group) of omeprazole. Levels of the micronutrients of interest (magnesium, vitamin B12, ferritin, transferrin saturation and iron) were quantified in serum samples. Differences in their levels over time were investigated using Friedman's analysis of variance. The accumulated incidence of magnesium deficiency (<0.7mM), vitamin B12 (150ρM) and iron (ferritin <30μg/L) were calculated at T1 and T2. Logistic regression models calculated the odds ratio for the development of deficiency between the OMP and CTR groups. In relation to T0, vitamin B12 levels decreased at T2 both in the OMP (P=.001) and CTR (P=.003) groups; transferrin saturation decreased at T2 only in the OMP group (P=.025). The levels of the other micronutrients did not change over time. The incidence of magnesium, vitamin B12 and iron deficiency did not differ between the OMP and CTR groups at T1 or T2. There was no significant odds ratio between the use of omeprazole and magnesium, vitamin B12 or iron deficiency in T1 or T2. These effect estimates were tested for moderation effects for the following covariates: gender, age, Charlson's comorbidity index, presence of diseases (type 2 diabetes mellitus, neoplasms, thyroid diseases or diseases for which omeprazole use is indicated), kidney function, ultra-sensitive c-reactive protein and the use of medications (diuretics, metformin, non-steroidal anti-inflammatory drugs, antithrombotics, calcium and vitamin D); no moderation effect was found. This work contributes to the understanding of the relationship between the use of proton pump inhibitors and the deficiency of magnesium, vitamin B12 and iron, whose causality remains controversial.