Navegando por Palavras-chave "Viral hepatitis"

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    Autoantibodies before, during and after administration of recombinant interferon-alpha for chronic viral hepatitis
    (Instituto de Medicina Tropical, 1995-10-01) Lopes, Edmundo P.a. [UNIFESP]; Silva, Antonio Eduardo Benedito [UNIFESP]; Sette Junior, Hoel; Guimarães, Rubens X. [UNIFESP]; Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Hospital Oswaldo Cruz
    This study was undertaken to investigate the presence of autoantibodies in patients with chronic viral hepatitis B and C, before, during and after interferon-alpha (IFN-alpha) therapy and to study their relation to dose and type of IFN-alpha and response to treatment. Fifty patients with chronic hepatitis were divided in two groups, a control-group of 21 patients (10 type B and 11 type C) who were followed for 6 months without treatment and an IFN-group consisting of 29 patients (8 type B and 21 type C) who received IFN therapy for 6 months. Serum samples were tested for a range of antibodies at the start of the study, during therapy and at the end of the 6 month period. Antibodies tested for included: antinuclear, smooth muscle, antimitochondrial, parietal cell and thyroid microsomal. Four (8%) of the total patient group had autoantibodies at the beginning of the study (two in each group). During the follow-up period no patient in the control group developed antibodies compared with 3 (11%) patients in the treatment group. Autoantibodies developed in patients treated with higher doses of IFN and were found in those patients who tended to show a poor response to IFN-therapy. Further studies are needed to establish the relationship between poor response to IFN-alpha and development of autoantibodies.
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    Practical Considerations of Real Life of Hepatocellular Carcinoma in a Tertiary Center of Brazil
    (Mexican Assoc Hepatology, 2017) Almeida-Carvalho, Sandra R. [UNIFESP]; Gomes-Ferraz, Maria L. [UNIFESP]; Loureiro-Matos, Carla A. [UNIFESP]; Benedito-Silva, Antonio E. [UNIFESP]; Carvalho-Filho, Roberto J. [UNIFESP]; Renato-Perez, Rogerio [UNIFESP]; Miziara-Gonzalez, Adriano [UNIFESP]; Salzedas-Netto, Alcides A. [UNIFESP]; Szejnfeld, Denis [UNIFESP]; D'Ippolito, Giuseppe [UNIFESP]; Pereira-Lanzoni, Valeria [UNIFESP]; Souza-Silva, Ivonete S. [UNIFESP]
    Background. Hepatocellular carcinoma (HCC) is the most common maligancy that develops in cirrhotic livers. Its clinical and epidemiological characteristics and morality rates vary according to geographical region. The objective of this study was to evaluate the clinical profile. epidemiological characteristics, laboratory parameters, treatment and survival of patients with HCC. Material and methods. Patients with HCC seen between 2000 and 2012 were studied. The Kapalan-Meier method was used for survival analysis according to variable in question. Results. The study included 247 patients with a mean a age of 60 +/- 10 years. There was a pre-dominance of males (74%). The main etiologies of HCC were HCV infection (55%), excessive alcohol consumption (12%), and HBV infection (8%). Liver cirrhosis was present in 92% of cases. The mean tumor number and diameter were 2 and 5 cm, respectively. Patients meeting the Milan criteria corresponded to 43% of the sample. Liver transplantation was performed in 22.4% of patients of the Milan subset and in 10% of the whole sample. The overall mean survival was 60 months,with a 1-, 3- and 5-year survival probability of 74%, 40% and 29%, respectively. Lower survival was observed among patients with alcoholic etiology. Survival was higher among patients submited to liver transplantation (P < 0.001), TACE (P < 0.001), or any kind of treatment (P < 0.001), However, no difference was found for surgical resection (P = 0.1) or sorafenib (P = 0.1). Conclusion. Patients with HCC were mainly older men diagnosed at an advanced stage. Treatment was associated with better overall survival, but few patients survived to be treated.