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- ItemAcesso aberto (Open Access)Efeitos do treinamento muscular inspiratório na função pulmonar de pacientes com Ataxia Telangiectasia(Universidade Federal de São Paulo (UNIFESP), 2011-03-30) Félix, Erika [UNIFESP]; Costa-Carvalho, Beatriz Tavares [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Background: Ataxia Telangiectasia (A-T) is an autosomal recessive syndrome, characterized by defects in DNA repair or replication which is caused by a mutation in a gene on the chromosome 11. The typical manifestations are cerebellar ataxia, telangiectasia and progressive muscular weakness. Besides, they also have a restrictive ventilatory pattern due to gradual loss of muscle strength, resulting in increased susceptibility to lung infections and severe respiratory failure. Although there is a lot of data about the effects of inspiratory muscle training in patients with chronic pulmonary diseases, there are no studies that correlate its effects specifically in A-T patients. Objective: To evaluate the effects of IMT on inspiratory muscle strength and its impact on pulmonary function and on quality of life of patients with A-T. Methods: This is a controlled, longitudinal intervention. We have selected 11 patients with A-T and 9 healthy controls matched for age and sex. A-T patients and controls underwent an inicial evaluation protocol that included: (i) measuring of ventilometry to obtain the minute volume (MV), tidal volume (VT), vital capacity (VC), respiratory rate (f) and ( ii) manovacuometry assessing the maximum inspiratory pressure (MIP) and maximal expiratory pressure (MEP). In this same phase, patients with A-T underwent further evaluation of (iii) quality of life using the SF-36 and (iv) application of the Borg scale for assessment of perceived shortness of breath. These same parameters were evaluated in the A-T group in the post-IMT period. The IMT protocol was initiated with a load of 40% of MIP, with weekly increases of 5%, up to 60% of MIP, which is the target load. The IMT was performed for 20 minutes daily during 24 weeks. Results: A-T patients, when compared with the control group, showed a significant difference in weight and height (36.91 ± 91vs 54.22 ± 8.80, p = 0.001), MIP and MEP in absolute terms (p <0.001) as percentage of predicted (p <0.001 and p = 0.009), and VC (p <0.001), respectively. In the post-IMT period, A-T patients showed a significant increase in VT (476.5 ± 135 ml vs 583.3 ± 66 ml, p = 0.015), VC (1664 ± 463 ml/kg vs 2145 ± 750 ml/kg , p = 0.002), MIP (22.2 ± 2 cmH2O vs 38 ± 9 cmH2O, p <0.001), MEP (29 ± 7 cmH2O vs 40 ± 8 cmH2O, p = 0.001), and significant decrease in f (23 , 3 ± 6 rpm vs 20.4 ± 4 rpm, p = 0.018) compared to baseline IMT. There was a decrease in the Borg/dyspnoea ratio (p = 0.022) and improvement in the domains of the SF-36 related to general health (p = 0.009) and vitality (p = 0.014). Conclusion: IMT was significantly effective in increasing muscle strength, with subsequent improvement in lung function in patients with A-T and should be considered an adjunctive therapy to drug treatment to improve quality of life of these patients.
- ItemAcesso aberto (Open Access)O treinamento inspiratório com threshold aumenta a sensibilidade à insulina de pacientes idosos portadores de resistência à insulina(Universidade Federal de São Paulo (UNIFESP), 2010-03-31) Silva, Mayra dos Santos [UNIFESP]; Lopes, Guiomar Silva [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The physiological degenerations in the aging process can cause physiological decline in the pulmonary and metabolic function, being able to affect in the elder quality of life. The aging is association with insulin resistance, characterized for the reduction of the insulin reply to the stimulations, whose gradual effect can take the glucose intolerance and diabetes type 2. Therefore, the objective in this study was to investigate the influence of the inspiratory muscular training through the Threshold® on the insulin resistance in aged people. The study involved the participation of 14 elder voluntaries, with age between 61 and 82 years old, sedentaries, with BMI between 18,75 - 36,7 and insulin resistants with lipids alterations, of both genders, without previous pulmonary and cardiovascular disease at the clinic of the Taipas Hospital. The selected patients have been submitted to the Laboratorial Test, the physical Test and Cardiopulmonary Test. After the test, the patients were divided in two groups: Control group and Experimental Group. The program had duration of 12 weeks and both the groups did the inspiratory muscle training 07 times per week, being 06 times domiciliary and 01 time in the clinic with duration of 30 minutes daily. All tests were repeated after 12 weeks of inspiratory muscle training, where the comparison between the groups after the period of study showed that the group that suffered intervention got an improvement of the respiratory muscular performance and force, reduction of metabolic values. It being considered statistical significant the reduction of the values in glicemic, insulin and HOMA IR, this is important because the correlation between aging and insulin resistance. The data suggest that the inspiratory muscle training improves the insulin sensibility in insulin resistance patients.