Navegando por Palavras-chave "Treinamento físico aeróbico"

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    Efeito do treinamento físico aeróbico na hipertrofia cardíaca de ratos espontaneamente hipertensos: papel do sistema ubiquitina proteassoma
    (Universidade Federal de São Paulo (UNIFESP), 2013-08-28) Andrade, Luiz Henrique Soares de [UNIFESP]; Medeiros, Alessandra [UNIFESP]; http://lattes.cnpq.br/0071198026371230; Universidade Federal de São Paulo (UNIFESP)
    Hypertension is a clinical condition that contributes to the development of cardiac hypertrophy. The activity level of the ubiquitin proteasome system (UPS) is involved in the initiation and progression of cardiac hypertrophy. Moreover, physical training can decrease blood pressure, reduce or reverse the pathological cardiac hypertrophy and this response may, at least in part, occur through changes in the activity of the SUP in the heart. The purpose of this study was to investigate the effect of aerobic exercise training in cardiac hypertrophy and activity of UPS in spontaneously hypertensive rats (SHR). For this, we used Wistar and SHR rats (8 weeks old) randomly divided into sedentary and trained, and the exercise training protocol was 5x/week in treadmill, low intensity, 60 min, for 13 weeks. Before, during and after the experimental period exercise tolerance test was performed. The recording indirect systolic blood pressure (SBP), heart rate (HR) and body weight were evaluated once a week. The proteasome activity in the catalytic site of chymotrypsin was measured by fluorimetric assay. The tr aining significantly increased exercise tolerance in hypertensive animals, decreased SBP and HR at rest after the period, and elevated diastolic function. In addition, it restored the proteasome activity on the control groups levels. Data from this study demonstrated the important non-pharmacological therapeutic effect of exercise on ubiquitin proteasome system in hypertension.
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    Efeito do treinamento físico aeróbico sobre a resposta vasomotora de ratas ovariectomizadas
    (Universidade Federal de São Paulo (UNIFESP), 2014-02-26) Nogueira, Viviane Aparecida Vieira [UNIFESP]; Medeiros, Alessandra [UNIFESP]; http://lattes.cnpq.br/0071198026371230; Universidade Federal de São Paulo (UNIFESP)
    BP reduction, however, is not yet well established effect of aerobic exercise on vasomotor response in the absence of estrogen. The present study examined the effect of aerobic exercise training on vasomotor response of ovariectomized rats. The sample consisted of female Wistar rats divided to 4 groups: sedentary and trained ovariectomized trained and sedentary (OVX and OVX-TRE) control (SHAM and SHAM-TRE). The results showed that groups OVX and OVX-TRE showed an increase in body mass and flow blood pressure during the weeks after ovariectomy, however, after the 5th of experiment group OVX-TRE showed a reduction in gain body and tail arterial pressure mass when compared to group OVX. After the 7th without experiment, group SHAM-TRE had a reduction in body weight compared to the SHAM group. The group OVX showed a lower endothelium dependent vasodilation, and this response was prevented in the group OVX-TRE by aerobic training. The endothelium dependent vasodilation of the group SHAM-TRE was close to the values of the group SHAM. On the other hand, endothelium independent vasodilation was not different between the groups. The level of reactive oxygen species was higher in the group OVX compared with the other groups (SHAM, SHAM-TRE and OVX-TRE), thus aerobic training was able to reduce the production of reactive oxygen species in the vessel group OVX-TRE. The results suggest that physical training promotes improved body composition and decreasing blood pressure levels of ovariectomized rats, besides contributing to the improvement of vasomotor response and reduced superoxide anion production in the vessel, even in estrogen deficiency.