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    Efeitos do extrato de cupuaçu sobre o estresse oxidativo e nitrosativo, marcadores inflamatórios e epigenéticos renais em modelo de diabetes mellitus
    (Universidade Federal de São Paulo (UNIFESP), 2017-05-31) Punaro, Giovana Rita [UNIFESP]; Higa, Elisa Mieko Suemitsu [UNIFESP]; Rogero, Marcelo Macedo; http://lattes.cnpq.br/6607279993080828; http://lattes.cnpq.br/8578252701813423; http://lattes.cnpq.br/2663314345767991; Universidade Federal de São Paulo (UNIFESP)
    Objective: To evaluate the effects of the cupuaçu extract on nitrosative stress, inflammatory and epigenetic renal markers in diabetes mellitus model. Methods: Immortalized mouse mesangial cells (MiMC) were placed in medium with normal glucose (NG) or high glucose (HG), with or without extract of cupuaçu (EC, 500, 100, 50 or 10 μg/mL) during 24, 48 or 72 h for analysis of viability, proliferation, nitric oxide (NO) and reactive oxygen species (EROS). Male, adult Wistar rats were randomized into 4 groups: control (CTL) and diabetic (DM) who received water; CTLEC and DMEC who received 1 mL/day of EC (1 g/mL), via gavage for 8 weeks. The DM and DMEC rats became diabetic after receiving an intravenous injection of streptozotocin (45 mg/kg). After 8 weeks of treatment, metabolic profile and renal function were evaluated. The kidneys were collected and used for the analysis of NO, EROS and protein content of nitrotyrosine, eNOS, IL-6, IL-10, TNF-α, NF-kB p65, TGF-β1/2/3, iNOS, HDAC1, HDAC2 and HDAC3. Results: MiMC showed a normal viability in all groups, demonstrating that EC had no cytotoxic effects at studied doses and times. There was a significant increase in proliferation in the HG group, as well as in the NO and EROS levels, and these parameters were significantly reduced after EC treatment in the MiMC after 72 h. Treatment with EC in diabetic animals resulted in a partial normalization of metabolic and renal function parameters with significant reduction on NO and EROS production, nitrotyrosine, eNOS, IL-6, TGF-β1/2/3 and iNOS; as well as an increased HDAC3 compared to the DM group. Conclusion: Daily EC intake could contribute to better control of oxidative and nitrosative stress, associated with reduction of inflammatory factors and modulation of epigenetic, suggesting the importance of bioactive compounds of EC as non-pharmacological adjuvant to delay the early renal complications in diabetic patients.
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    Síntese, caracterização e aplicação de biossorvente híbrido nanomodificado (BNM) a partir de resíduo de levedura da indústria sucroalcooleira impregnado com nanopartículas ferromagnéticas (Fe3O4)
    (Universidade Federal de São Paulo, 2017-10-06) Debs, Karina Bugan [UNIFESP]; Araújo, Geórgia Christina Labuto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The clean water access is a global problem that concerns the organizations involved in public health. In this context, the employment of hybrid nanomodified biosorbent (NMB) from yeast residue of ethanol industry, impregnated with magnetite nanoparticles (Fe3O4), for oils and dyes removal from aqueous solution were investigated. The oils studies revealed that temperature is the most relevant parameter in the oil removal process. The best removal for new motor oil and petroleum 28 °API happened at low temperatures, and were, respectively, 3522  118 g kg-1 e 2157  281 g kg-1. However, for mixed used motor oils, the removal was 2841  280 g kg-1, presenting this result at higher temperatures. All the experimental data followed the D-optimum and neural network models. Regarding the dyes, the composite showed a similar sorption capacity than the yeast biomass. Therefore, the composite uses were justified due to the simple and fast removal of the material from aqueous medium when a magnetic field is applied. In methylene blue sorption, both, yeast biomass and the composite, were well adjusted to SIPS model, which is a combination of Langmuir and Freundlich models, showing that the sorption process includes chemicals and physicals phenomenon’s. The magnetite nanoparticles have low affinity with methylene blue, indicating that, in the composite, some interactions occur between the nanoparticles and the yeast biomass. In textile wastewater sorption, the composite and yeast biomass sorption capacity were, respectively, 10,9  0,5 mg g-1 e 13,0  2,0 mg g-1.