Navegando por Palavras-chave "Transtorno Afetivo Bipolar"

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    Alteração Da Expressão Gênica Relacionada A Sintomas Psicóticos E De Mania Em Pacientes Em Primeiro Episódio Psicótico Virgens De Tratamento
    (Universidade Federal de São Paulo (UNIFESP), 2017-05-31) Gouvea, Eduardo Sauerbronn [UNIFESP]; Belangero, Sintia Iole Nogueira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Psychoses are among serious mental disorders and affect approximately 3% of the general population. In the initial stages, the non-specific syndromic clinical aspects do not allow diagnostic clarity between the tables. The broad psychopathological nuance in the First Psychotic Episode (PEP) reinforces the need to investigate biomarkers that refine early diagnosis. We investigated the difference in gene expression among patients with schizophrenic symptoms (PEP-S, N = 53), with manifest symptoms (PEP-M, N = 16) and healthy controls (N = 76). We also analyzed the variation of gene expression with the severity of psychotic symptoms, manifested symptoms, depressive symptoms, and functional performance. All participants were treatment-naive with antipsychotics. After blood collection, 12 genes related to psychotic manifestations were evaluated by quantitative PCR. The expression levels of AKT1 and DICER1 were higher in patients with manifest symptoms (PEP-M) when compared to both patients with schizophrenic symptoms (PEP-S) and controls, suggesting that the expression of these genes is more specific to the occurrence of manifest symptoms . The expression of the MBP and NDEL1 genes was higher among the patients (both PEP-S and PEP-M) than in the healthy controls indicating a relationship with the psychotic manifestation itself independent of the diagnosis. We found no correlation between the levels of gene expression and the severity of symptoms or functional performance. Our findings suggest that the expression of genes related to neurodevelopment is altered in the psychoses, and can thus serve the differential diagnosis between schizophrenia and bipolar affective disorder and consequently to a better therapeutic definition.