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    Structural analysis and unique molecular recognition properties of a Bauhinia forficata lectin that inhibits cancer cell growth
    (Wiley-Blackwell, 2017) Lubkowski, Jacek; Durbin, Sarah V.; Silva, Mariana C. C. [UNIFESP]; Farnsworth, David; Gildersleeve, Jeffrey C.; Oliva, Maria Luiza V. [UNIFESP]; Wlodawer, Alexander
    Lectins have been used at length for basic research and clinical applications. New insights into the molecular recognition properties enhance our basic understanding of carbohydrate-protein interactions and aid in the design/development of new lectins. In this study, we used a combination of cell-based assays, glycan microarrays, and X-ray crystallography to evaluate the structure and function of the recombinant Bauhinia forficata lectin (BfL). The lectin was shown to be cytostatic for several cancer cell lines included in the NCI-60 panel