Navegando por Palavras-chave "Teratogens"

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    Effects of ethanol on offspring of C57BL/6J mice alcoholized during gestation
    (Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 1999-09-01) Grinfeld, Hermann; Goldenberg, Saul [UNIFESP]; Segre, Conceição Aparecida De Mattos; Chadi, Gerson; University of São Paulo; Universidade Federal de São Paulo (UNIFESP); Albert Einstein Hospital
    The effects of chronic alcohol consumption during pregnancy were analysed in the gestation and offspring of alcoholized mice. Female C57BL/6J mice were placed overnight with stud males and the presence of a sperm plug in the next morning indicated the onset of gestation. Pregnant mice were distributed in two weight-matched groups. In the alcoholized group, the mice received a high protein liquid diet ad libitum containing 27.5% of ethanol-derived calories (5.28% v/v) from gestation day 5 to 19. The control group received the same volume of diet containing isocaloric amounts of maltose-dextrin substituted for ethanol. After postnatal day zero, the dams received food pellets and tap water ad libitum. On postnatal day 6 the pups were counted and weighed at variable intervals up to the 60th day of life. The majority of the pregnant dams that have received ethanol completed the gestational period, and the chronic consumption of alcohol did not interfere with the number of dams that gave birth. The alcoholized and control dams gained an equivalent weight and consumed an equivalent volume of diet throughout the gestation. The number of pups from alcohol diet dams was 46,26% smaller compared with the control group. There were less male than female pups in the offspring of alcoholized mice. Teratogeny like gastroschisis and limb malformation were present in the offspring of alcoholized dams. The body weight of the offspring of alcoholized mice increased from the 18th to the 36th postnatal day.
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    Teratogen exposure and congenital ocular abnormalities in Brazilian patients with Möbius sequence
    (Conselho Brasileiro de Oftalmologia, 2014-10-01) Ventura, Camila Vieira Oliveira Carvalho; Ventura, Liana Maria Vieira de Oliveira; Miller, Marilyn T.; Cronemberger, Monica Fontenele [UNIFESP]; Dias, Carlos Sousa [UNIFESP]; Dias, Maria Joaquina Marques; Gonzalez, Claudete H.; Polati, Mariza; Nakanami, Célia Regina; Brandt, Carlos Teixeira; Kuczynski, Evelyn; Goldchmit, Mauro; Fundação Altino Ventura Department of Ophthalmology; Hospital de Olhos de Pernambuco Department of Ophthalmology; University of Illinois Department of Ophthalmology & Visual Science; Universidade Federal de São Paulo (UNIFESP); Associação de Assistência à Criança Deficiente; Santa Casa de Misericórdia de São Paulo Department of Ophthalmology; Universidade de São Paulo (USP); Universidade Federal de Pernambuco Department of Pediatric Surgery; Services Group in Epileptic Child Psychiatry; Instituto Cema Department of Ophthalmology
    Purpose: To assess the sociodemographic profiles, teratogen exposures, and ocular congenital abnormalities in Brazilian patients with Möbius sequence. Method: Forty-four patients were recruited from the Brazilian Möbius Sequence Society. This cross-section comprised 41 patients (age, mean ± standard deviation, 9.0 ± 5.5 years) who fulfilled the inclusion criteria. The parent or caregiver answered a questionnaire regarding sociodemographic data and pregnancy history. Patients underwent ophthalmological assessments. They were subdivided into groups according to misoprostol exposure during pregnancy, and the two groups were compared. Results: Mothers/caregivers reported unplanned pregnancies in 36 (88%) cases. Of these, 19 (53%) used misoprostol during their first trimesters. A stable marital status tended to be more frequent in the unexposed group (P=0.051). Incomplete elementary school education was reported by two (11%) mothers in the exposed group and by three (14%) mothers in the unexposed group (P=0.538). The mothers' gestational exposures to cocaine, marijuana, alcohol, and cigarettes were similar in both groups (P=0.297, P=0.297, P=0.428, and P=0.444, respectively). One (5%) case of Rubella infection during pregnancy was found in the unexposed group. The main malformations in the exposed and unexposed groups were the following: strabismus (72% and 77%, respectively), lack of emotional tearing (47% and 36%, respectively), and lagophthalmos (32% and 41%, respectively). Conclusion: Stable marital statuses tended to be more frequent among mothers that did not take misoprostol during pregnancy. Exposures to other teratogens and the main ocular abnormalities were similar in both groups.