Navegando por Palavras-chave "Terapia A Laser"

Agora exibindo 1 - 2 de 2
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Comparação entre as técnicas de panfotocoagulação utilizando laser 577 nm de multidisparos versus panfotocoagulação convencional no tratamento da retinopatia diabética
    (Universidade Federal de São Paulo (UNIFESP), 2021) Passos, Renato Magalhaes [UNIFESP]; Farah Neto, Michel Eid [UNIFESP]; Universidade Federal de São Paulo
    Purpose: To compare the outcomes after panretinal photocoagulation (PRP) with two different strategies for treating diabetic retinopathy (DR), based in criteria such as laser parameters, therapeutic response, and patient tolerance. Methods: This single-center, randomized clinical study included 41 eyes with proliferative or severe non-proliferative DR. They were treated in group 1 with 577 nanometer (nm) multispot laser and 20 milliseconds (ms) pulse duration, while in group 2 they were treated with so-called conventional PRP with 532 nm single-spot laser and 100 ms pulse duration. The outcomes included functional evaluation with best-corrected visual acuity (BCVA) and structural evaluation with imaging methods (OCT and fluorescein angiogram) at baseline, 6 and 12 months. Other variables included laser parameters, number of PRP applications required, and results of a subjective pain analysis. Results: The multispot laser (group 1) required fewer PRP applications and more laser spots delivered (P<0.001) to compensate for lower fluence/pulse duration and provided a similar pain sensibility compared with single-spot laser. Both groups maintained the initial VAs and CRTs; about 50% of cases had vitreomacular interface changes and improved macular edema, with similar angiographic improvements after 12 months. New vessels regression was seen less frequently in both groups, possibly because of baseline disease severity rather than the treatment modality. Conclusions: Multispot laser demonstrated to be equivalent and non-inferior to conventional treatment with single spot laser for diabetic retinopathy, offering some advantages such as smaller number of sessions to finish PRP and a lower fluence to obtain the desired results, producing less retinal iatrogenic damage.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Inovação tecnológica para termoablação de tumores de cabeça e pescoço com terapia termica de laser indução associada à cisplatina CDDP-LITT
    (Universidade Federal de São Paulo (UNIFESP), 2021) Palumbo, Marcel Das Neves [UNIFESP]; Paiva, Marcos Bandiera [UNIFESP]; Universidade Federal de São Paulo
    The thermal ablation of tumors by laser has been growing as a multidisciplinary subspecialty defined as LITT, mainly due to high demand of less invasive procedures to patients in palliative care. In this therapy, high doses of thermal energy are directed to the central area of the tumor, causing irreversible damage to tumor cells, but smaller doses are directed to outlying areas, causing reversible changes, maintaining the tumor viability, consequentially with high risk of recurrence. The association with chemotherapeutic drugs, mainly cisplatin (CDDP), has been studied with satisfactory results, decreasing the possibility of recurrence. Since the first studies of cisplatin, the local effect can be strengthened by LITT( LITT-CDDP procedure), since the heat increases intracellular uptake and the susceptibility of the cell to cytotoxicity. In this study, we developed new prototype with dual Laser 1470nm + 450nm and intratumoral cisplatin. Further studies are required to assess the security in higher doses, the increase in number of applications, especially important in high-volume tumors.