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    Dinâmica da transmissão familiar do SARS-CoV-2 entre profissionais de saúde e pacientes de dois hospitais da cidade de São Paulo
    (Universidade Federal de São Paulo (UNIFESP), 2021) Carvalho, Joseane Mayara Almeida [UNIFESP]; Bellei, Nancy Cristina Junqueira [UNIFESP]; Universidade Federal de São Paulo
    Objective: To evaluate the dynamics of SARS-CoV-2 transmission in family groups of healthcare workers and patients in two hospitals in the city of São Paulo: Hospital São Paulo (HSP) and Hospital Infantil Sabará (HIS). Methods: Sixty index cases with Coronavirus Disease 2019 (COVID-19) were selected: 30 health professionals from the HSP and their 93 household contacts; and 30 patients from the HIS and their 89 household contacts. Asymptomatic and symptomatic individuals participating in the study were tested for COVID-19 and followed for 14 days. However, If the result was positive, a new collection was not performed. Otherwise, a new collection was performed in the second week to carry out a more rigorous epidemiological investigation. Tests were performed by reverse transcription followed by real-time polymerase chain reaction assay (RT-qPCR). Results: 242 family members were tested. The secondary attack rate in the HSP family groups of healthcare workers was 37.6% (95% CI 0.28-0.47), while in the HIS group of patients, the attack rate was 68. 5% (95% CI 0.58-0.77). The attack rate of infection in the families of patients treated at the HIS was higher than that observed in the families of healthcare workers from the HSP, indicating a different pattern in the dynamics of SARS-CoV-2 infection in family groups of healthcare workers and patients. The average number of days that a family member tested positive for SARS-CoV-2, after the index case result, was 4 days for home contacts of healthcare workers and 3 days for home contacts of patients. Conclusion: Home contacts of HIS patients were the most infected. The higher attack rate in this group is probably due to the fact that healthcare workers have a greater perception of the risk of transmission and greater knowledge of preventive methods.