Navegando por Palavras-chave "TLE"

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    Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy
    (Nature Publishing Group, 2012-03-01) Almeida, Sandro Soares [UNIFESP]; Naffah-Mazzacoratti, Maria da Graca [UNIFESP]; Guimarães, Paola Bianchi [UNIFESP]; Wasinski, Frederick [UNIFESP]; Pereira, Flavia Enira Gomes [UNIFESP]; Canzian, Mauro [UNIFESP]; Centeno, Ricardo Silva [UNIFESP]; Carrete Junior, Henrique [UNIFESP]; Yacubian, Elza Márcia Targas [UNIFESP]; Carmona, Adriana Karaoglanovic [UNIFESP]; Vieira, Renata de Freitas Fischer [UNIFESP]; Nakaie, Clovis Ryuichi [UNIFESP]; Sabatini, Regiane Angelica [UNIFESP]; Perosa, Sandra Regina [UNIFESP]; Bacurau, Reury Frank Pereira; Gouveia, Telma Luciana Furtado [UNIFESP]; Gallo, Gloria [UNIFESP]; Wuertele, Martin [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Silva Junior, Jose Antonio [UNIFESP]; Pesquero, João Bosco [UNIFESP]; Araujo, Ronaldo de Carvalho [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Nove de Julho Univ UNINOVE
    We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012
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    Dysmorphic neurons in patients with temporal lobe epilepsy
    (Elsevier B.V., 2006-02-09) Silva, A. V. da; Houzel, J. C.; Yacubian, Elza Márcia Targas [UNIFESP]; Carrete, H.; Sakamoto, A. C.; Priel, M. R.; Martins, H. H.; Oliveira, I; Garzon, E.; Stavale, J. N.; Centeno, R. D.; Machado, H.; Cavalheiro, E. A.; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio de Janeiro (UFRJ); Universidade de São Paulo (USP)
    We studied morphologic characteristics of dysmorphic neurons in the hippocampus of seven patients with medically intractable TLE and compare histological, clinical, and imaging features with ten TLE patients with classical hippocampal sclerosis without abnormal cells. Such dysmorphic neurons were observed in the hilus of the dentate gyrus and were characterized by giant or misshapen cells with abnormal cytoskeletal structure and atypical dendritic processes that resembled the dysmorphic neurons from cortical dysplasias. Specimens with dysmorphic cells also contained other cyto architectural abnormalities including bilamination of the clentate granular cell layer (four out seven cases), and the presence of Cajal-Retzius cells in the dentate gyrus or Ammon's horn (five out seven cases). There were no statistically significant differences regarding the age at onset, duration of epilepsy, and hippocampal asymmetry ratio between patients with or without dysmorphic cells. Nevertheless, it is interesting to note that a higher proportion of patients with dysmorphic neurons continued to present auras after surgery, when compared with patients without those cells. (c) 2005 Elsevier B.V. All rights reserved.
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    Modulation of B-1 and B-2 kinin receptors expression levels in the hippocampus of rats after audiogenic kindling and with limbic recruitment, a model of temporal lobe epilepsy
    (Elsevier B.V., 2008-02-01) Pereira, Marilia G. A. G.; Gitai, Daniel L. G.; Paco-Larson, Maria L.; Pesquero, Joao B. [UNIFESP]; Garcia-Cairasco, Norberto; Costa-Neto, Claudio M.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Epileptic seizures are hypersynchronous, paroxystic and abnormal neuronal discharges. Epilepsies are characterized by diverse mechanisms involving alteration of excitatory and inhibitory neurotransmission that result in hyperexcitability of the central nervous system (CNS). Enhanced neuronal excitability can also be achieved by inflammatory processes, including the participation of cytokines, prostaglandins or kinins, molecules known to be involved in either triggering or in the establishment of inflammation. Multiple inductions of audiogenic seizures in the Wistar audiogenic rat (WAR) strain are a model of temporal lobe epilepsy (TLE), due to the recruitment of limbic areas such as hippocampus and amygdata. in this study we investigated the modulation of the B-1 and B-2 kinin receptors expression levels in neonatal WARs as well as in adult WARs subjected to the TLE model. the expression levels of pro-inflammatory (IL-1 beta) and anti-inflammatory (IL-10) cytokines were also evaluated, as well as cyclooxygenase (COX-2). Our results showed that the B-1 and B-2 kinin receptors mRNAs were up-regulated about 7- and 4-fold, respectively, in the hippocampus of kindled WARs. On the other hand, the expressions of the IL-1 beta, IL-10 and COX-2 were not related to the observed increase of expression of kinin receptors. Based on those results we believe that the B, and B2 kinin receptors have a pivotal role in this model of TLE, although their participation is not related to an inflammatory process. We believe that kinin receptors in the CNS may act in seizure mechanisms by participating in a specific kininergic neurochemical pathway. (c) 2007 Elsevier B.V. All rights reserved.