Navegando por Palavras-chave "Técnica Indireta De Fluorescência Para Anticorpo"

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    Pesquisa De Podocitúria: Desenvolvimento E Padronização De Métodos
    (Universidade Federal de São Paulo (UNIFESP), 2018-02-22) Pereira, Amelia Rodrigues [UNIFESP]; Kirsztajn, Gianna Mastroianni [UNIFESP]
    Introduction: Podocytes Are Fundamental Cells For Maintaining The Functionality Of The Glomerular Filtration Barrier, Which Is Characterized By Selective Permeability. Podocyturia, Excretion Of Podocytes In Urine, Has Been Studied In Several Glomerulopathies As A Potential Marker Of Disease Activity. It Is A Non-Invasive Method That Can Reflect In Real Time The Podocyte Lesion, And It Can Be A More Sensitive And Earlier Marker Of This Kind Of Lesion. It Presents Potential Applicability In Assessing The Activity Of Glomerular Diseases And Understanding Their Pathogenesis, As Well As Guiding Future Therapeutic Interventions. Objectives: To Standardize And Validate The Methodology For The Investigation Of Podocyturia By Two Techniques, Indirect Immunofluorescence And Quantification By Polymerase Chain Reaction In Real Time, In Addition To Determine Which Technique Is Most Suitable For This Purpose. Material And Methods: The Study Of Podocyturia Occurred In A Group Of 71 Individuals, 21 (29,17%) Patients With Foc