Navegando por Palavras-chave "Stromal Cells"

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    Gordura obtida de procedimentos em cirurgia plástica, células-tronco derivadas do tecido adiposo e seu potencial em inovação tecnológica: revisão narrativa de literatura
    (Universidade Federal de São Paulo (UNIFESP), 2021) Lamblet, Hebert Teixeira [UNIFESP]; Ferreira, Lydia Masako [UNIFESP]; Universidade Federal de São Paulo
    introduction: in clinical practice, stem cells derived from adipose tissue (ADSC) are generally not administered isolated, but as a constituent of the stromal vascular fraction (SVF). Although plastic surgery has a bright history of innovation, the recent search for new therapies and methods in this specialty and more recently in regenerative medicine has heated up the market for a continuous search for innovations and technologies for the use of these cells of the SVF in an ethical, efficient way and easy to reproduce. Objective: to carry out a narrative review of the literature on plastic surgery procedures that use fat as a product, which involve obtaining ADSC and its potential for technological innovation in this processing. Method: a narrative literature review was carried out using the works published from January 1993 to August 2020, in English, Portuguese and Spanish, in the MEDLINE/PubMed databases. After the selection, exploratory reading, selective reading, material selection, text analysis, interpretive reading and writing were performed. Results: Of the 33 articles selected for the review, it was found that 23 articles used the enzymatic dissociation method to isolate stem cells derived from adipose tissue (ADSC), 25 articles reported that the plastic surgery procedure used was liposuction and 23 articles reported innovation technology using 3D models. Conclusions: The most used method for the isolation of ADSC was enzymatic dissociation, liposuction the most practiced procedure in plastic surgery and 3D models the most found innovation technology.
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    Mesenchymal stem cells as therapeutic candidates for halting the progression of diabetic nephropathy
    (Univ Sao Paulo, Conjunto Quimicas, 2016) Paulini, Janaina; Higuti, Eliza; Bastos, Rosana M. C.; Gomes, Samirah A.; Rangel, Erika B. [UNIFESP]
    Mesenchymal stem cells (MSCs) possess pleiotropic properties that include immunomodulation, inhibition of apoptosis, fibrosis and oxidative stress, secretion of trophic factors, and enhancement of angiogenesis. These properties provide a broad spectrum for their potential in a wide range of injuries and diseases, including diabetic nephropathy (DN). MSCs are characterized by adherence to plastic, expression of the surface molecules CD73, CD90, and CD105 in the absence of CD34, CD45, HLA-DR, and CD14 or CD11b and CD79a or CD19 surface molecules, and multidifferentiation capacity in vitro. MSCs can be derived from many tissue sources, consistent with their broad, possibly ubiquitous distribution. This article reviews the existing literature and knowledge of MSC therapy in DN, as well as the most appropriate rodent models to verify the therapeutic potential of MSCs in DN setting. Some preclinical relevant studies are highlighted and new perspectives of combined therapies for decreasing DN progression are discussed. Hence, improved comprehension and interpretation of experimental data will accelerate the progress towards clinical trials that should assess the feasibility and safety of this therapeutic approach in humans. Therefore, MSC-based therapies may bring substantial benefit for patients suffering from DN.