Navegando por Palavras-chave "Sodium glutamate"
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- ItemAcesso aberto (Open Access)Efeito da sobreposição de um modelo de obesidade neuroendócrina experimental e hipertensão arterial sobre a pressão arterial, peso corporal e parâmetros metabólicos e renais de ratos(Sociedade Brasileira de Nefrologia, 2011-09-01) Ferreira, Lara Beatriz Delfino [UNIFESP]; Cesaretti, Mario Luis Ribeiro; Voltera, Aline Francisco [UNIFESP]; Ginoza, Milton [UNIFESP]; Kohlmann Junior, Osvaldo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Pontifícia Universidade Católica de São PauloINTRODUCTION: Increased body mass index and the metabolic syndrome are associated with decreased renal function and the development of end-stage kidney disease. OBJECTIVE: To evaluate the effect of the overlap between an experimental model of obesity and genetic hypertension on the blood pressure, body weight and metabolic and kidney parameters of rats. METHODS: We studied male rats of the Wistar (WST) and spontaneously hypertensive rats (SHR) strains. Monosodium glutamate (MSG) was administered in the neonatal period to both strains, to make up two groups: WST + MSG and SHR + MSG. Animals in the control groups (WST and SHR) received saline. After completing three months of life, a 12-week follow-up period ensued, during which bi-weekly measurements of body weight (BW) and tail-cuff blood pressure (TCBP) were obtained. Microalbuminuria was analyzed at weeks 0, 4, 8 and 12. At the end of the follow-up period, blood was obtained for fasting glucose, plasma creatinine, and lipid profile determinations. The kidneys were removed, stained, and the glomerular sclerosis index was calculated. RESULTS: The administration of MSG produced higher percentage body weight gain, higher fasting blood glucose and a higher degree of glomerular injury in WST-MSG and MSG-SHR rats, compared to their controls. Greater urinary albumin excretion was observed in SHR + MSG rats, when compared to SHR. There was no statistical difference in the TCBP, creatinine, and lipid profile. CONCLUSIONS: The association of neuroendocrine obesity and arterial hypertension promoted morphological and functional changes in the glomerulus. These changes were more severe than those observed in hypertensive-only rats.
- ItemSomente MetadadadosEfeito do jejum em ratos com obesidade induzida pelo glutamato monossódico(Universidade Federal de São Paulo (UNIFESP), 1991) Ribeiro, Eliane Beraldi [UNIFESP]; Dolnikoff, Miriam Sterman [UNIFESP]