Navegando por Palavras-chave "Sistemas De Liberação De Medicamentos"

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    Estudo da qualidade dos frascos multidose dos colírios: adequação, segurança e melhorias
    (Universidade Federal de São Paulo (UNIFESP), 2021) Costa, Alexandre Xavier Da [UNIFESP]; Gomes, Jose Alvaro Pereira [UNIFESP]; Universidade Federal de São Paulo
    Objectives: The purpose of this thesis was to contribute to quality improvement of multidose eyedrops by analyzing factors related to appropriate eyedrop packaging, identifying safety issues and user perceptions of eyedrop usability, assessing drop volume variability and the impact of eyedrop bottle tip geometry and instillation angle on contamination rates, with the aim of encouraging specification of requirements for topical ophthalmic products. Methods: From the identification of the multidose eyedrops marketed in Brazil, 297 packages and package inserts were analyzed for informational content, alongside an analysis of the variability of the drop volume and the correlation of the mass per drop measured in five samples of five lubricant eyedrop brands and an evaluation of the performance of five samples of six eyedrops on an airplane during varying altitudes. Risk of cross contamination of six samples from nine brands of multidose eyedrops that were contaminated exclusively on the exterior side of rounded versus sharp tips was measured at instillation angles of 45° and 90° degrees. A survey aiming at a qualitative analysis of the perception, knowledge, usability and consumption trends of eyedrop was administered to 1.003 consumers. Results: Eyedrops represent 91.6% of ophthalmic drugs currently sold in Brazil. The mean drop volume reported by the manufacturers was 36.9 ± 7 µL, ranging from 25.6 to 71.4 µL. Instructions for using eyedrops are uneven and not illustrative, and some products were found to have inadequate package inserts. In the performance test at high altitude, one brand presented leakage and an irregular efflux of drops in all samples. An increased risk of infection transmission was observed in vials with a rounded tip versus a sharp tip [69.4% vs. 22.2%, P=0.001], especially when inclined at an instillation angle of 45° versus 90° [83.3% vs. 44.4%, P=0.005]. Among the 1,003 survey respondents, 84.6% indicated experiencing a part of the eyedrop running over the face upon instillation and 76.2% preferred to have information regarding the total number of drops contained in the eyedrop bottles. Conclusions: The data indicate a possible inadequacy and lack of standardization of eyedrop packaging and bottles, which yield drops of excess volume for the human eye. Moreover, eyedrop bottles with perpendicular platform tips showed greater safety than those with rounded nozzles. Manufacturers should inform the total number of drops in each product, in addition to total net volume. A review of user instructions and requirements for quality standards for the registration of ophthalmic products is recommended.
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    Síntese, Caracterização E Determinação Do Potencial Antimicrobiano De Nanopartículas Superparamagnéticas De Óxido De Ferro Funcionalizadas Com O Peptídeo Antimicrobiano Ocelatina Pt7 Dissertação
    (Universidade Federal de São Paulo (UNIFESP), 2018-08-30) Oyadomari, William Yoshio Agliardi [UNIFESP]; Daghastanli, Katia Regina Perez [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Recently, Many Studies Have Focused On The Development Of Drug Carriers To Bring A Bioactive Molecule To Target Tissue Using Lower Doses Of The Drug And Thus Reducing Its Toxicity. In This Work We Develop And Characterize Nanoparticles Of Superparamagnetic Iron Oxide (Spion) Bound To Ocelatina Pt7, An Antimicrobial Peptide. The Nanoparticles Were Synthesized Using The Co-Precipitation Method Of Iron (Iii) And Iron (Ii) (2: 1 Mol / Mol) With Nh4oh In The Presence Of Oleic Acid Under A Nitrogen Atmosphere And Under Stirring. The Final Suspension Of Nanoparticles Responded To The Magnetic Field Generated By A Magnet And Was Characterized By Dynamic Light Scattering (Dls), Zeta Potential (Zp), Fourier Transform Infrared Spectroscopy (Ftir), Scanning Electron Microscopy (Sem), Crystallography Of X-Ray And Optical Microscopy. Nanoparticles Not Coated With Oleic Acid Have A Hydrodynamic Diameter Of 1400 Nm, A Zp Of -23 Mv And Coalesce Rapidly. The Coating With Oleic Acid Decreased The Hydrodynamic Diameter Of The Na