Navegando por Palavras-chave "Sistema ubiquitina proteassoma"

Agora exibindo 1 - 1 de 1
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Efeito do treinamento físico aeróbico na hipertrofia cardíaca de ratos espontaneamente hipertensos: papel do sistema ubiquitina proteassoma
    (Universidade Federal de São Paulo (UNIFESP), 2013-08-28) Andrade, Luiz Henrique Soares de [UNIFESP]; Medeiros, Alessandra [UNIFESP]; http://lattes.cnpq.br/0071198026371230; Universidade Federal de São Paulo (UNIFESP)
    Hypertension is a clinical condition that contributes to the development of cardiac hypertrophy. The activity level of the ubiquitin proteasome system (UPS) is involved in the initiation and progression of cardiac hypertrophy. Moreover, physical training can decrease blood pressure, reduce or reverse the pathological cardiac hypertrophy and this response may, at least in part, occur through changes in the activity of the SUP in the heart. The purpose of this study was to investigate the effect of aerobic exercise training in cardiac hypertrophy and activity of UPS in spontaneously hypertensive rats (SHR). For this, we used Wistar and SHR rats (8 weeks old) randomly divided into sedentary and trained, and the exercise training protocol was 5x/week in treadmill, low intensity, 60 min, for 13 weeks. Before, during and after the experimental period exercise tolerance test was performed. The recording indirect systolic blood pressure (SBP), heart rate (HR) and body weight were evaluated once a week. The proteasome activity in the catalytic site of chymotrypsin was measured by fluorimetric assay. The tr aining significantly increased exercise tolerance in hypertensive animals, decreased SBP and HR at rest after the period, and elevated diastolic function. In addition, it restored the proteasome activity on the control groups levels. Data from this study demonstrated the important non-pharmacological therapeutic effect of exercise on ubiquitin proteasome system in hypertension.