Navegando por Palavras-chave "Saline Solution, Hypertonic"

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    Efeitos iniciais da reposição volêmica com solução salina hipertônica a 7,5% na perfusão e oxigenação esplâncnica após choque hemorrágico
    (Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2006-04-01) Cruz Junior, Ruy Jorge; Yada-Langui, Margareth M.; Garrido, Alejandra Gallardo; Poli de Figueiredo, Luiz Francisco [UNIFESP]; Silva, Mauricio Rocha e; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    PURPOSE: To evaluate the effects of SSH resuscitation on systemic and splanchnic hemodynamic variables in an experimental model of controlled hemorrhagic shock. METHODS: Ten mongrel dogs were bled (20 ml/min) to a target mean arterial pressure (MAP) of 40±5 mmHg. After 30 minutes of shock, animals received SSH infused in 5-minute and they were observed for 60 minutes thereafter. Systemic hemodynamics were evaluated through a Swan-Ganz and arterial catheters while gastrointestinal tract perfusion by a catheter inside the portal vein, an ultrasonic flowprobe around portal vein blood flow (PVBF) and a gastric tonometer. Splanchnic oxygen delivery and consumption, intramucosal pH and veno-arterial, portal-arterial and mucosal-arterial pCO2-gradients (Dap-a pCO2, Dvp-a pCO2 e Dt-a pCO2, respectively) were assessed. RESULTS: Hemorrhage (29.8±2.4ml/Kg) induced significant decreases in MAP (125±6 to 42±1 mmHg), in CO (1.9±0.2 to 0.6±0.1 L/min), and PVBF (504±73 to 126±12 ml/min) while significant increases were detected in Dap-a pCO2 (5.3±0.8 to 19.9±1.6 mmHg) Dvp-a pCO2 (5.4±1.4 to 22.6±2.1 mmHg) and Dt-a pCO2 (6.1±1.1 to 43.8±7.5 mmHg). SSH infusion promoted only partial benefits in systemic and splanchnic blood flows. Reduced pCO2 gradients but fewer effects in Dt-a pCO2 were observed. CONCLUSION: The SSH infusion promoted partial systemic and splanchnic hemodynamic benefits. Those benefits were especially poor at the splanchnic microcirculation, as evaluated by Dt-a pCO2. In addition, systemic and regional oxygen-derived variables do not reflect the regional microcirculation disturbances. Gastrointestinal tonometry clearly represents a useful tool for monitoring splanchnic perfusion in patients in hemodynamic shock.
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    Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats
    (Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2014-11-01) Marques, Geraldo Magela Nogueira; Rasslan, Roberto; Belon, Alessandro Rodrigo; Carvalho, Juliana Gonçalves; Felice Neto, Raphael; Rasslan, Samir; Utiyama, Edivaldo Massazo; Montero, Edna Frasson de Souza [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    PURPOSE:To evaluate intestinal inflammatory and apoptotic processes after intestinal ischemia/reperfusion injury, modulated by pentoxifylline and hypertonic saline.METHODS:It was allocated into four groups (n=6), 24 male Wistar rats (200 to 250g) and submitted to intestinal ischemia for 40 min and reperfusion for 80 min: IR (did not receive any treatment); HS group (Hypertonic Saline, 4ml/kg-IV); PTX group (Pentoxifylline, 30mg/kg-IV); HS+PTX group (Hypertonic Saline and Pentoxifylline). All animals were heparinized (100U/kg). At the end of reperfusion, ileal fragments were removed and stained on hematoxylin-eosin and histochemical studies for COX-2, Bcl-2 and cleaved caspase-3.RESULTS:The values of sO2 were higher on treated groups at 40 minutes of reperfusion (p=0.0081) and 80 minutes of reperfusion (p=0.0072). Serum lactate values were lower on treated groups after 40 minutes of reperfusion (p=0.0003) and 80 minutes of reperfusion (p=0.0098). Morphologic tissue injuries showed higher grades on IR group versus other groups: HS (p=0.0006), PTX (p=0.0433) and HS+PTX (p=0.0040). The histochemical study showed lesser expression of COX-2 (p=0.0015) and Bcl-2 (p=0.0012) on HS+PTX group. A lower expression of cleaved caspase-3 was demonstrated in PTX (p=0.0090; PTXvsIR).CONCLUSION:The combined use of pentoxifylline and hypertonic saline offers best results on inflammatory and apoptotic inhibitory aspects after intestinal ischemia/reperfusion.