Navegando por Palavras-chave "Renal afferent activation"

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    Total renal denervation reduces sympathoexcitation to different target organs in a model of chronic kidney disease
    (Elsevier Science Bv, 2017) Veiga, Glaucia L.[UNIFESP]; Nishi, Erika E.[UNIFESP]; Estrela, Heder F.[UNIFESP]; Lincevicius, Gisele S.[UNIFESP]; Gomes, Guiomar N.; Simoes Sato, Alex Y.[UNIFESP]; Campos, Ruy R.[UNIFESP]; Bergamaschi, Cassia T.[UNIFESP]
    It is known that increased sympathetic nerve activity in chronic kidney disease (CKD) progressively worsens kidney function and hypertension. We tested the hypothesis that total renal denervation contributes to reduce sympathetic activation to different beds and improves renal function in 5/6 nephrectomy model of CKD in male Wistar rats. After eight weeks of 5/6 nephrectomy surgery there was an increase in mean arterial pressure (CKD 179 +/- 22 mm Hg, n = 6 vs. control animals 108 +/- 9