Navegando por Palavras-chave "Reinstantement"

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    Investigação da participação de pequenos grupos neurais seletivamente ativados do hipocampo dorsal na reinstalação da autoadministração de etanol induzido pelo contexto
    (Universidade Federal de São Paulo (UNIFESP), 2019-05-30) Jesus, Jaqueline Moreira Felipe de [UNIFESP]; Cruz, Fabio Cardoso [UNIFESP]; http://lattes.cnpq.br/4804337113083801; http://lattes.cnpq.br/1762079560232831; Universidade Federal de São Paulo (UNIFESP)
    Drug relapse is the major problem in drug addiction. Environmental contexts previously associated with drug use cause relapse to drug use in humans and reinstatement of drug seeking in animal models. Here, we evaluated the role of dorsal hippocampus in context-induced reinstatement of alcohol seeking in rats. To assess a causal role for this brain region, we trained male rats to self-administrate alcohol in context A and extinguished their lever-pressing in Context B. On the test day, animals were re-exposed to the alcohol context A or the extinction context B for 30 min. Context-induced reinstatement was associated with increased expression of the immediate early genes fos in CA1, CA3 and Dentate Gyrus hippocampus subregion. Cobalt Chloride injection into CA1 region attenuated context-induced reinstatement of ethanol seeking, without affecting the locomotor activity. Further, Daun02 injection into CA1 region attenuated context-induced alcohol seeking. Our data suggest that context-induced reinstatement of alcohol seeking is mediated by activation of context-selected dorsal hippocampus neuronal ensembles.