Navegando por Palavras-chave "Pulmonary function tests"

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    Avaliação da função pulmonar em lactentes com doença falciforme
    (Universidade Federal de São Paulo (UNIFESP), 2017) Ivankovich, Danilo Turcato [UNIFESP]; Wandalsen, Gustavo Falbo [UNIFESP]; Braga, Josefina Aparecida Pellegrini [UNIFESP]; Lanza, Fernanda de Cordoba [UNIFESP]; http://lattes.cnpq.br/7645872510889651; http://lattes.cnpq.br/5288152697269527; http://lattes.cnpq.br/4807350957191775; http://lattes.cnpq.br/6334142370202939; Universidade Federal de São Paulo (UNIFESP)
    Objective: To assess lung function in infants with sickle cell disease and to compare with a group of infants who did not have sickle cell or lung diseases. Methods: A cross-sectional study was carried out with patients between 6 and 18 months of age that, after being submitted to a clinical evaluation and sedation with chloral hydrate, underwent the pulmonary function testing through lung volume analysis by whole-body plethysmography, and forced expiratory flows using rapid thoracoabdominal compression with raised lung volume. The parameters were recorded in absolute value, z score and percentage of predicted. Statistical analysis tests were considered significant with p <0.05. Results: 33 patients with sickle cell disease were evaluated, with a mean age of 12.6 months (± 3.3), 67% were males, and compared to 37 controls, with a mean age of 10.3 months (± 1.2), 41% male. The groups differed in asthma family history and gestational smoking, these being more prevalent in the control group. The adjusted analysis of the forced expiratory flows showed significantly lower values in the sickle cell group compared with the controls, this occurred in different parameters, such CVF (-0,39 ± 0,8 vs 0,58 ± 0,5), VEF0,5 (-0,43 ± 0,8 vs 0,82 ± 0,5), FEF25-75 (0,03 ± 0,9 vs 1,03 ± 0,7), FEF50 (-0,04 ± 0,8 vs 0,99 ± 0,7), all with p<0,001. No differences were observed in lung volumes and pulmonary capacities. Serum levels of lactic dehydrogenase were correlated only with CRF (r = -0.32 p = 0.04), hemoglobin levels and reticulocytes did not correlate with pulmonary function values. In the comparison between sickle cell genotypes (HbSS, n = 22 or HbSC, n = 11), FEF50 was significantly lower in patients with SS genotype (p = 0.046). Both genotypes presented significant differences in relation to the control group, being these differences greater in the SS genotype. The pulmonary function testing was altered in 27% of the patients, 78% of them with obstructive pattern. Conclusions: Pulmonary function may be reduced in the first years of life in sickle cell disease, with great variability in flow values and predominance of obstructive alterations. Although we observed most significant differences in patients with HbSS, patients with HbSC also might have altered lung function.
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    Efficacy of the FEV1/FEV6 ratio compared to the FEV1/FVC ratio for the diagnosis of airway obstruction in subjects aged 40 years or over
    (Associação Brasileira de Divulgação Científica, 2007-12-01) Rosa, Fernanda Warken [UNIFESP]; Pérez-Padilla, Rogelio; Camelier, Aquiles Assunção [UNIFESP]; Nascimento, Oliver Augusto [UNIFESP]; Menezes, Ana Maria Baptista; Jardim, José Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Católica do Salvador; Faculdade de Tecnologia e Ciências; National Institute of Respiratory Diseases; Universidade Federal da Bahia Disciplina de Pneumologia; Universidade Federal de Pelotas Programa de Pós-graduação em Epidemiologia; PLATINO Group
    The present cross-sectional, population-based study was designed to evaluate the performance of the FEV1/FEV6 ratio for the detection of airway-obstructed subjects compared to the FEV1/FVC <0.70 fixed ratio test, as well as the lower limit of normality (LLN) for 1000 subjects ³40 years of age in the metropolitan area of São Paulo, SP, Brazil. After the exclusion of 37 (3.7%) spirometries, a total of 963 pre-bronchodilator (BD) and 918 post-BD curves were constructed. The majority of the post-BD curves (93.1%) were of very good quality and achieved grade A (762 curves) or B (93 curves). The FEV1/FEV6 and FEV1/FVC ratios were highly correlated (r² = 0.92, P < 0.000). Two receiver operator characteristic curves were constructed in order to express the imbalance between the sensitivity and specificity of the FEV1/FEV6 ratio compared to two FEV1/FVC cut-off points for airway obstruction: equal to 70 (area under the curve = 0.98, P < 0.0001) and the LLN (area under the curve = 0.97, P < 0.0001), in the post-BD curves. According to an FEV1/FVC <0.70, the cut-off point for the FEV1/FEV6 ratio with the highest sum for sensitivity and specificity was 0.75. The FEV1/FEV6 ratio can be considered to be a good alternative to the FEV1/FVC ratio for the diagnosis of airway obstruction, both using a fixed cut-off point or below the LLN as reference. The FEV1/FEV6 ratio has the additional advantage of being an easier maneuver for the subjects and for the lung function technicians, providing a higher reproducibility than traditional spirometry maneuvers.