Navegando por Palavras-chave "Protection"
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- ItemSomente MetadadadosB-1 cell protective role in murine primary Mycobacterium bovis bacillus Calmette-Guerin infection(Elsevier B.V., 2010-12-01) Russo, Ricardo T.; Mariano, Mario [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)B-1 cells were first described in the early 1980s and are distinct from conventional B lymphocytes in respect to phenotype, morphology, ontogeny, tissular distribution and function. Although many years have been past since their description, B-1 cells role within the immune system is still unclear. Years ago, our lab demonstrated that B-1 cells were able to differentiate into macrophage-like mononuclear phagocytes that could migrate to the acute inflammatory focus induced by a foreign body in vivo. We also showed that B-1 cells were pivotal for the formation of foreign-body giant cells. Studies using B-1-cell-defiecient mice (Xid mice), suggested B-1 cells have a participation in immune responses to infections. This led us to investigate whether B-1 cells would also have a participation in a model of infection-generated chronic inflammation. Using Xid mice and adoptive transfer of cultured B-1 cells, we investigated the influence of these cells on some of the immune events triggered by Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection in mice. We found that B-1 cells are present in the BCG-induced pulmonary lesions and can migrate from peritoneal cavity to the infected lung, modulate the histological pattern of the inflammation, influence the influx of other cells to the infected lung and favor the resistance to the mycobacteria. Altogether, our results demonstrate that peritoneal B-1 cells play a key role in the inflammatory reaction to BCG, clarifying a new aspect of the biology of these versatile cells. (C) 2010 Elsevier GmbH. All rights reserved.
- ItemAcesso aberto (Open Access)Caracterização de materiais obtidos pela reciclagem de vestimentas de proteção biológica(Universidade Federal de São Paulo, 2020-10-15) Skurczenski, Nina Cordeiro [UNIFESP]; Moraes, José Ermírio Ferreira de [UNIFESP]; http://lattes.cnpq.br/4692364565124711; http://lattes.cnpq.br/7949670315160899No cenário atual de alto consumo de produtos plásticos, torna-se cada vez mais relevante o estudo de maneiras de otimizar o reaproveitamento de resíduos sólidos. Neste contexto, um exemplo de resíduo que é largamente emitido pela indústria está relacionado aos equipamentos de proteção individual que devem ser descartados após o uso. O presente trabalho teve como objetivo o estudo do processo de reciclagem de macacões de proteção individual feitos de polietileno de alta densidade (Tyvek®, desenvolvido pela empresa DuPont™) e a posterior caracterização do material obtido, realizando-se uma análise comparativa com o uso de materiais provenientes de dois diferentes ambientes e, consequentemente, apresentando dois níveis de contaminação distintos, a saber: (a) macacões usados em ambientes de salas limpas (amostra I) e (b) macacões contendo resíduos de fibras de vidro (amostra II). No processo de reciclagem, os macacões passaram, em uma primeira etapa, por uma triagem manual, seguindo para um posterior processo de moagem, realizado em moinho de facas, e, finalmente, seguindo para o reprocessamento em uma extrusora de dupla rosca. Analisando-se os materiais das amostras I e II, foram obtidos valores próximos para alguns parâmetros físicos, a saber: densidade de ~0,95 g/cm³ e resistência à tração e à flexão de ~34 MPa e ~12 MPa, respectivamente. Os ensaios térmicos apresentaram valores médios de temperatura de fusão de ~137 °C e temperatura de degradação de ~475 °C. Os ensaios de fluidez apresentaram maior diferença entre os dois materiais, sendo o índice de fluidez de 0,778 g/10 min para a amostra I e 0,901 g/10 min para a amostra II. Tais resultados foram confirmados com a análise de reologia rotacional, obtendo viscosidades de cisalhamento de 24,101 Pa.s e 16,781 Pa.s, respectivamente. Comparando os resultados dessas análises, foi possível observar que os materiais reciclados apresentaram valores distantes dos apresentados pelo material de origem (Tyvek®), impossibilitando o seu uso para a mesma aplicação. Por outro lado, os materiais obtidos apresentaram diversos parâmetros com valores característicos dos polietilenos de alta densidade, fato que pode possibilitar a sua reutilização em outras aplicações na cadeia produtiva, desenvolvendo um sistema de economia circular.
- ItemAcesso aberto (Open Access)A criança em abrigos: a proteção e o cuidado de bebês em acolhimento institucional(Universidade Federal de São Paulo (UNIFESP), 2019-12-17) Lima, Mariana Parro [UNIFESP]; Freitas, Marcos Cezar De [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)This research brought the reflection on the protection of babies in institutional foster care. This is a study of ethnographic inspiration that, by analyzing the concrete situation of 12 babies identified in a host institution in the municipality of Piracicaba, from 2015 to 2017, sought to capture the relationships and interactions that occurred there, then, to highlight the plots they raise, bringing together the complexities and contradictions that exist, both in the reality of the institutionalization of babies and young children, and in the discourse that supports it. The main objective of the research was to investigate how the experience of child shelter re-signifies, in current terms, the social meaning of the word protection and, as a result of this, sought to unveil the sense of protection that permeates concrete experiences of institutionalization. For that, the main theoretical references were the authors Fúlvia Rosemberg, Erving Goffman, and Robert Castel. The senses of protection and care employed by the different actors in the research scenario were discussed and, in the current context, are structuring aspects of the care of young children, when removed from their biological parents. We sought to contribute to childhood studies, exploring the theme of resignification of child shelter as a social form of protection and care, and which express not only institutional aspects, but also a perspective to research the social construction of responsibility on children. The studied institution showed some possible ways when the concern with the child and his family becomes the focus of the practices and actions in the shelter. The research revealed that, in practice, little has been achieved in terms of working with families of origin, those in extreme conditions of social vulnerability. There is a complexity of its own only observable when observed "closely." Analyzing their occurrences, it is possible to deconstruct the idea of a naturalness that accompanies the representations of social structure as something natural and in a progressive march to assist everyone. It was concluded that the services available are precarious, with no investment by the government in new alternative care or abandonment prevention services methodologies.
- ItemAcesso aberto (Open Access)Destombamentos No Estado De São Paulo Ambiguidades E Transformações Na Atribuição De Valores Aos Bens Culturais(Universidade Federal de São Paulo (UNIFESP), 2018-08-09) Assis, Bruna Aparecida Silva De [UNIFESP]; Rufinoni, Manoela Rossinetti [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The Presented Research Proposes To Investigate The Subjects Involved In The Denominated "Protection Cancellation" Of A Cultural Property, An Administrative Appeal Which Use Has Increased Recently, Despite Its Exceptional Features. The Aim Is The Understanding, In The Preservation Public Policies Context Of The São Paulo State, Which Are The Reasons And Agents Involved In The Protection Cancellation, How It"S Been Used And Which Are The Problematics It Aggregates, While It Turns The Brazil"S Most Used Legal Instrument Of Property Protection Ineffective. From The Analysis Of Three Case Studies: Igreja De São Gonçalo (São Paulo/Sp), Casa Do Sítio Piraquara (São Paulo/Sp) And Mansão Matarazzo (São Paulo), Belonging, Respectively, To The Three Spheres Of Protection That Act In The São Paulo State, Iphan, Condephaat E Conpresp, This Research Intends To Identify And To Problematize The Main Causes, Discussions And Repercussions Associated To The Protection Cancellation Of A Cultural Property.
- ItemSomente MetadadadosPrevious exercise training increases levels of ppar-alpha in long-term post-myocardial infarction in rats, which is correlated with better inflammatory response(Hospital clinicas, univ sao paulo, 2016) Higuchi Santos, Marilia Harumi; Higuchi, Maria de Lourdes; Tucci, Paulo J. F. [UNIFESP]; Garavelo, Sherrira M.; Reis, Marcia M.; Antonio, Ednei L. [UNIFESP]; Serra, Andrey J.; Maranhao, Raul CavalcanteOBJECTIVE: Exercise is a protective factor for cardiovascular morbidity and mortality, with unclear mechanisms. Changing the myocardial metabolism causes harmful consequences for heart function and exercise contributes to metabolic adjustment modulation. Peroxisome proliferator-activated receptors (PPARs) are also myocardium metabolism regulators capable of decreasing the inflammatory response. We hypothesized that PPAR-alpha is involved in the beneficial effects of previous exercise on myocardial infarction (MI) and cardiac function, changing the expression of metabolic and inflammatory response regulators and reducing myocardial apoptosis, which partially explains the better outcome. METHODS AND RESULTS: Exercised rats engaged in swimming sessions for 60 min/day, 5 days/week, for 8 weeks. Both the exercised rats and sedentary rats were randomized to MI surgery and followed for 1 week (EI1 or SI1) or 4 weeks (EI4 or SI4) of healing or to sham groups. Echocardiography was employed to detect left ventricular function and the infarct size. Additionally, the TUNEL technique was used to assess apoptosis and immunohistochemistry was used to quantitatively analyze the PPAR-alpha, TNF-alpha and NF-kappa B antigens in the infarcted and non-infarcted myocardium. MI-related mortality was higher in SI4 than in EI4 (25% vs 12%), without a difference in MI size. SI4 exhibited a lower shortening fraction than EI4 did (24% vs 35%) and a higher apoptosis/area rate (3.97 +/- 0.61 vs 1.90 +/- 1.82) in infarcted areas (both p=0.001). Immunohistochemistry also revealed higher TNF-alpha levels in SI1 than in EI1 (9.59 vs 4.09, p<0.001) in infarcted areas. In non-infarcted areas, EI4 showed higher levels of TNF-alpha and positive correlations between PPAR-alpha and NF-kappa B (r=0.75, p=0.02), in contrast to SI4 (r=0.05, p=0.87). CONCLUSION: Previously exercised animals had better long-term ventricular function post-MI, in addition to lower levels of local inflammatory markers and less myocardial apoptosis, which seemed to be related to the presence of PPAR-alpha.