Navegando por Palavras-chave "Prognostic biomarkers"

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    Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer
    (Baishideng Publishing Group Inc, 2016) da Silva Oliveira, Kelly Cristina; Thomaz Araujo, Taissa Maira; Albuquerque, Camila Inagaki; Barata, Gabriela Alcantara; Gigek, Carolina Oliveira [UNIFESP]; Leal, Mariana Ferreira [UNIFESP]; Wisnieski, Fernanda [UNIFESP]; Rodrigues Mello Junior, Fernando Augusto; Khayat, Andre Salim; de Assumpcao, Paulo Pimentel; Rodriguez Burbano, Rommel Mario; Smith, Marilia de Arruda Cardoso [UNIFESP]; Calcagno, Danielle Queiroz
    Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of miRNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on miRNA activity.