Navegando por Palavras-chave "Premature infant"

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    Immune response to tetanus booster in infants aged 15 months born prematurely with very low birth weight
    (Elsevier B.V., 2012-10-12) Perin, Maria Cristina Abrão Aued [UNIFESP]; Schlindwein, Carolina Frank [UNIFESP]; Moraes-Pinto, Maria Isabel de [UNIFESP]; Simao-Gurge, Raquel Maria [UNIFESP]; Mimica, Ana Flavia de Mello Almada [UNIFESP]; Goulart, Ana Lucia [UNIFESP]; Santos, Amélia Miyashiro Nunes dos [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objectives: To compare humoral and cellular immune responses to tetanus booster vaccination in infants born prematurely with those born at full term and identify factors associated with the humoral response.Methods: A prospective study was carried out on children born prematurely and with a birth weight <1500g and with infants born at full term. At 15 months (pre-vaccination) and 18 months (post-vaccination), anti-tetanus antibodies were measured by ELISA; the intracellular interferon-gamma percentages of CD4+ T and CD8+ T cells after in vitro stimulation with tetanus toxoid were determined by flow cytometry. Chi-squared or Fisher's exact test was used to compare categorical variables. Student's t-test or Mann-Whitney test was used to compare numerical variables. Regression analysis was performed to determine factors associated with humoral immunity. Statistical significance was considered if p < 0.05.Results: Sixty-four premature and 54 full-term infants were studied. the proportion of children immune against tetanus at 15 and 18 months was similar in both groups. the geometric mean of the antibodies was lower among the premature children at 15 months (p = 0.025) and was similar in both groups at 18 months (p = 0.852). the percentages of CD4+ and CD8+ T cells expressing intracellular IFN-gamma were similar in both groups at 15 and 18 months. Gestational age <32 weeks was associated with a reduction of 0.116 IU/mL in the level of antibodies at 15 months. Breastfeeding >6 months was associated with a 3.5-fold greater chance of optimal protective (>= 0.1 IU/mL) antibody level against tetanus at 15 months and an increase of 0.956 in the level of antibodies at 18 months.Conclusions: Humoral and cellular response following a tetanus booster was similar in both groups. Premature infants exhibited lower levels of anti-tetanus antibodies at 15 months of age, with the lowest levels in those born at a gestational age of less than 32 weeks. Breastfeeding was associated with greater levels of antibody against tetanus. (C) 2012 Elsevier B.V. All rights reserved.
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    Multidimensional pain assessment of preterm newborns at the 1st, 3rd and 7th days of life
    (Associação Paulista de Medicina - APM, 2007-01-01) Serpa, Ana Beatriz Mello [UNIFESP]; Guinsburg, Ruth [UNIFESP]; Balda, Rita de Cássia Xavier [UNIFESP]; Dos Santos, Amelia Miyashiro [UNIFESP]; Areco, Kelsy Catherina Nena [UNIFESP]; Peres, Clovis de Araujo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    CONTEXT AND OBJECTIVE: It is challenge to assess and treat pain in premature infants. The objective of this study was to compare the multidimensional pain assessment of preterm neonates subjected to an acute pain stimulus at 24 hours, 72 hours and seven days of life. DESIGN AND SETTING: Prospective cohort study, at Universidade Federal de São Paulo (UNIFESP). METHODS: Eleven neonates with gestational age less than 37 weeks that needed venepuncture for blood collection were studied. The exclusion criteria were Apgar score < 7 at five minutes, presence of any central nervous system abnormality, and discharge or death before seven days of life. Venepuncture was performed in the dorsum of the hand, and the heart rate, oxygen saturation and pain scales [Neonatal Facial Coding System (NFCS), Neonatal Infant Pain Scale (NIPS), and Premature Infant Pain Profile (PIPP)] were assessed at 24 hours, 72 hours and 7 days of life. NFCS and NIPS were evaluated prior to procedure (Tpre), during venepuncture (T0), and two (T2) and five (T5) minutes after needle withdrawal. Heart rate, O2 saturation and PIPP were measured at Tpre and T0. Mean values were compared by repeated-measurement analysis of variance. RESULTS: The pain parameters did not differ at 24 hours, 72 hours and 7 days of life: heart rate (p = 0.22), oxygen saturation (p = 0.69), NFCS (p = 0.40), NIPS (p = 0.32) and PIPP (p = 0.56). CONCLUSION: Homogeneous pain scores were observed following venepuncture in premature infants during their first week of life.