Navegando por Palavras-chave "Prótese mecânica"

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    Evolução de longo prazo de próteses biológica e mecânica para cirurgia de valvas cardíacas. Revisão sistemática de estudos clínicos randomizados
    (Universidade Federal de São Paulo (UNIFESP), 2018-10-25) Kiyose, Alberto Takeshi [UNIFESP]; Moises, Valdir Ambrosio [UNIFESP]; http://lattes.cnpq.br/7272777672324904; http://lattes.cnpq.br/3383543123255106; Universidade Federal de São Paulo (UNIFESP)
    Background: The choice of a mechanical (MP) or biological prosthesis (BP) for patients with valvular heart disease undergoing replacement is still not a consensus. We aimed to determine the longterm clinical outcomes of MP or BP placement in those patients. Methods: We conducted a systematic review and metaanalysis of randomized controlled trials (RCTs) that compared biological prostheses and mechanical prostheses in patients with valvular heart diseases and assessed the longterm outcomes. RCTs were searched in the MEDLINE, EMBASE, LILACS, CENTRAL, SCOPUS and Web of Science (from inception to November 2014) databases. Metaanalyses were performed using inverse variance with random effects models. The GRADE system was used to rate the quality of the evidence. Results: A total of four RCTs were included in the metaanalyses (1,528 patients): three used old generation mechanical and biological prostheses, and one used contemporary prostheses. No significant difference in mortality was found between BP and MP patients (risk ratio (RR=1.07; 95% CI 0.991.15). The risk of bleeding was significantly lower in BP patients than MP patients (RR=0.64; 95% CI 0.520.78) ; however, reoperations were significantly more frequent in BP patients (RR=3.60; 95% CI 2.445.32). There were no statistically significant differences between BP and MP patients with respect to systemic arterial embolisms and infective endocarditis (RR= 0.93; 95% CI 0.661.31, RR= 1.21; CI95% 0.781.88, respectively). Results in the trials with modern and old prostheses were similar. Conclusions: The longterm mortality rate and the risk of thromboembolic events and endocarditis were similar between BP and MP patients. The risk of bleeding was approximately one third lower for BP patients than for MP patients, while the risk of reoperations was more than three times higher for BP patients.