Navegando por Palavras-chave "Polymer Induced Heteronucleation"

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    Crystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (pihn) method
    (Wiley-v c h verlag gmbh, 2016) Araya-Sibaja, Andrea Mariela; Soldi, Valdir; Maduro de Campos, Carlos Eduardo; Cardoso, Simone Goncalves; Cuffini, Silvia Lucia [UNIFESP]
    The selective crystallization of progesterone polymorphs prepared by Polymer-Induced Heteronucleation (PIHn) method was investigated. Polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), dextran, gelatin, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as heteronucleants. Crystallizations were conducted from 0.5,10 and 40 mg mL(-1) solutions in chloroform at room temperature by solvent evaporation. The samples were characterized by X-ray powder diffraction, differential scanning calorimetry, infrared spectroscopy and scanning electron microscopy. Form 2 was obtained from 0.5 mg mL(-1) solution in almost all polymers. A mixture of both poly morphs crystallized from the three concentrations on gelatine