Navegando por Palavras-chave "Pineal Gland"
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- ItemAcesso aberto (Open Access)O efeito da iluminação ambiental na atividade, no repouso e no nível de melatonina urinária de puérperas hospitalizadas.(Universidade Federal de São Paulo (UNIFESP), 2019-09-26) Volcov, Cristina Furtado [UNIFESP]; Coca, Kelly Pereira [UNIFESP]; Pinheiro, Eliana Moreira; http://lattes.cnpq.br/0313695891816024; http://lattes.cnpq.br/8167230363189115; http://lattes.cnpq.br/6547980567614545; Universidade Federal de São Paulo (UNIFESP)Introduction: Woman's organism undergoes physiological changes in the postpartum mediate. Changes on activity and rest may be increased by the need for exposure to artificial lighting at nighttime due to the care of the newborn. Objectives: To verify the effect of artificial ambient lighting on the activity, rest and urinary melatonin level of hospitalized postpartum women. Method: Pilot clinical trial with 21 postpartum women admitted to a rooming-in unit of a university hospital in São Paulo. Women with the following characteristics were included: aged ≥18 years, single pregnancy and ≥12 hours after delivery; without a history of psychiatric diseases, use of illicit drugs during pregnancy, thyroid disorders and/or sleep and night work in the last three years; whose child was born at term, healthy and was breastfeeding. Excluded were those with: blindness, obstetric complications and under use of medications (beta-blocker, diuretics, corticosteroids and/or central nervous system depressors) in the last 72 hours. The women were randomized to control and experimental groups. The intervention consisted on the exposure of the women to long wavelength light illumination during nighttime when they were hospitalized in a specific room with controlled environment lighting. The experimental room was prepared for exposure to the experiment’s artificial lighting. Women's characterization data were identified to assess group homogeneity by interview. The variables related to activity and rest were obtained from actimeter records, and the level of 6-sulfatoxymelatonin was identified by the Elisa Method after 24-hour urine collecting. Results: The control and experimental groups studied were homogeneous. Women in the experimental group had longer resting time at 24 hours; however, the total mean activity and rest were not statistically significant when compared to those in the control group (p=0.61 and p=0.57 respectively). Regarding the level of 6-sulfatoxymelatonin, the mean excreted was higher during the daytime in the experimental group and at night in the control group, with no significant difference (p=0.13 and p=0.13 respectively). The percentage of total load excreted in 24 hours was lower in the experimental group (p=0.04). Conclusion: The artificial illumination of the long wavelength environment did not interfere with the activity, rest and urinary melatonin level of hospitalized postpartum women. The average time of night rest of women hospitalized in rooming-in was considered adequate.
- ItemSomente MetadadadosEfeito da pinealectomia e/ou iluminação continua no número de corpos lúteos, ovócitos e na implantação em ratas albinas(Universidade Federal de São Paulo (UNIFESP), 2004) Teixeira, Alvaro Aguiar Coelho [UNIFESP]; Simôes, Manuel de Jesus [UNIFESP]Neste trabalho avaliamos os aspectos morfológicos e quantitativos dos sítios de implantações em úteros de ratas pinealectomizadas submetidas à iluminação constante. Os grupos experimentais foram: Grupo I ratas normais mantidas em ciclo claro/escuro de 12112 horas, durante dois meses, acasaladas em seguida e eutanasiadas no 6º dia de prenhez; (controle); Grupo II -ratas sham-pinealectomízadas mantidas em ciclo claro/escuro de 12/12 horas, durante dois meses, acasaladas em seguida e eutanasiadas no 6º dia de prenhez (controle); Grupo III - ratas pinealectomizadas, mantidas em ciclo claro/escuro de 12/12 horas, durante dois meses, acasaladas em seguida e eutanasiadas no 6º dia de prenhez; Grupo IV - ratas normais mantidas em iluminação constante durante dois meses, acasaladas em seguida e eutanasiadas no 6º dia de prenhez; Grupo V -ratas sham-pinealectomizadas, mantidas em iluminação constante durante dois meses, acasaladas em seguida e eutanasiadas no 6º dia de prenhez; Grupo VI - ratas pinealectomizadas, mantidas em iluminação constante durante dois meses, acasaladas em seguida e eutanasiadas no 6º dia de prenhez. A análise estatística das médias dos sítios de implantações mostrou que houve diferença significativa, onde os grupos III, IV, V e VI diferiram dos grupos I e II, os quais apresentaram as maiores médias. Os grupos III, IV, V e VI não diferiram entre si. A análise morfológica dos sítios nos grupos controles revelou a presença de pequenas lacunas contendo sangue, além de células trofoblasticas intermediárias, gigantes e alguns citotrofoblastos poliplóides. Nos grupos III, IV, V e VI evidenciou-se lacunas bem desenvolvidas nos sítios, com trofoblastos intermediários, citotrofoblastos com alto grau de poliploidia e sinciciotrofoblastos. Concluímos que a pinealectomia, a iluminação constante ou associação desses fatores levam a uma redução do número de blastocistos implantados em ratas, apesar de estimular o desenvolvimento desses sítios indicando assim que a melatonina pode ter importante função na viabilidade de implantação do blastocisto nesses animais.
- ItemSomente MetadadadosEfeitos da melatonina sobre o sistema reprodutor feminino(Universidade Federal de São Paulo (UNIFESP), 2008) Soares Júnior, José Maria [UNIFESP]
- ItemAcesso aberto (Open Access)Rat pinealectomy: a modified direct visual approach(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2009-08-01) Maganhin, Carla Cristina [UNIFESP]; Simões, Ricardo Santos; Fuchs, Luiz Fernando Portugal [UNIFESP]; Oliveira-Filho, Ricardo Martins; Simões, Manuel de Jesus [UNIFESP]; Evêncio Neto, Joaquim; Baracat, Edmund Chada [UNIFESP]; Soares Júnior, José Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Federal University of Pernambuco Department of Morphology Histology DivisionPURPOSE: To report a new, direct visual approach for rat pinealectomy. METHODS: Eighty adult female rats (Rattus norvegicus albinus EPM-1 strain) were weighted and anesthetized intraperitoneally with 15 mg/kg xylazine and 30 mg/kg ketamine. The animal was fastened to a dissection table, an incision was made in the skin and the subcutaneous tissue, bringing the lambda into view. The skullcap was opened with a dental drill, bringing the cerebral hemispheres and the superior sagittal sinus into view. The pineal gland, located under the venous sinus, was removed in a single piece using tweezers. Next, the bone fragment was returned to its place and the surgical layers were sutured. RESULTS: This new technique is easy to be done, avoids bleedings and removes only the pineal gland without damage to the remaining encephalon. In addition it makes possible the achievement of a sham surgery, allowing the pineal gland to remain intact. CONCLUSION: The proposed technique intends to facilitate studies aiming to better understanding the complexity and importance of the pineal gland on reproductive and other body systems.