Navegando por Palavras-chave "Passive avoidance task"

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    AMPA receptors mediate passive avoidance deficits induced by sleep deprivation
    (Elsevier B.V., 2013-11-15) Dubiela, Francisco Paulino [UNIFESP]; Queiroz, Claudio Marcos; Moreira, Karin Di Monteiro [UNIFESP]; Nobrega, Jose N.; Sita, Luciane Valeria; Tufik, Sergio [UNIFESP]; Hipólide, Débora Cristina [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Fed Rio Grande do Norte; Ctr Addict & Mental Hlth; Universidade de São Paulo (USP)
    The present study addressed the effects of sleep deprivation (SD) on AMPA receptor (AMPAR) binding in brain regions associated with learning and memory, and investigated whether treatment with drugs acting on AMPAR could prevent passive avoidance deficits in sleep deprived animals. [H-3]AMPA binding and GluR1 in situ hybridization signals were quantified in different brain regions of male Wistar rats either immediately after 96 h of sleep deprivation or after 24 h of sleep recovery following 96 h of sleep deprivation. Another group of animals were sleep deprived and then treated with either the AMPAR potentiator, aniracetam (25, 50 and 100 mg/kg, acute administration) or the AMPAR antagonist GYKI-52466 (5 and 10 mg/kg, acute and chronic administration) before passive avoidance training. Task performance was evaluated 2 h and 24 h after training. A significant reduction in [H-3]AMPA binding was found in the hippocampal formation of SD animals, while no alterations were observed in GluR1 mRNA levels. the highest dose of aniracetam (100 mg/kg) reverted SD-induced impairment of passive avoidance performance in both retention tests, whereas GYKI-52466 treatment had no effect. Pharmacological enhancement of AMPAR function may revert hippocampal-dependent learning impairments produced after SD. We argue that such effects might be associated with reduced AMPAR binding in the hippocampus of sleep deprived animals. (C) 2013 Elsevier B.V. All rights reserved.
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    Sleep deprivation impairs emotional memory retrieval in mice: Influence of sex
    (Elsevier B.V., 2012-08-07) Fernandes-Santos, Luciano [UNIFESP]; Patti, Camilla de Lima [UNIFESP]; Zanin, Karina Agustini [UNIFESP]; Fernandes, Helaine Arrais [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Frussa-Filho, Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The deleterious effects of paradoxical sleep deprivation on memory processes are well documented. However, non-selective sleep deprivation occurs more commonly in modern society and thus represents a better translational model. We have recently reported that acute total sleep deprivation (TSD) for 6 h immediately before testing impaired performance of male mice in the plus-maze discriminative avoidance task (PM-DAT) and in the passive avoidance task (PAT). in order to extend these findings to females, we examined the effect of (pre-test) TSD on the retrieval of different memory tasks in both male and female mice. Animals were tested using 3 distinct memory models: 1) conditioning fear context (CFC), 2) PAT and 3) PM-DAT. in all experiments, animals were totally sleep-deprived by the gentle interference method for 6 h immediately before being tested. in the CFC task and the PAT, TSD induced memory impairment regardless of sex. in PM-DAT, the memory impairing effects of TSD were greater in females. Collectively, our results confirm the impairing effect of TSD on emotional memory retrieval and demonstrate that it can be higher in female mice depending on the memory task evaluated. (C) 2012 Elsevier Inc. All rights reserved.