Navegando por Palavras-chave "Parvalbumin"

Agora exibindo 1 - 3 de 3
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Hippocampal plasticity in rats submitted to a gastric restrictive procedure
    (Maney Publishing, 2011-09-01) Freitas Sonoda, Elisa Yumi de; Silva, Sergio Gomes da [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Giglio, Pedro Nogueira; Margarido, Nelson Fontana; Real Martinez, Carlos Augusto; Pansani, Aline Priscila; Maciel, Rude de Souza; Cavalheiro, Esper Abrao; Scorza, Fulvio Alexandre [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Univ Sao Francisco; Fdn Univ Itaperuna FUNITA
    Bariatric surgery has been the most effective therapeutic intervention for morbidly obese patients. However, recent evidence has shown that this procedure may cause serious neurological complications such as Wernicke encephalopathy, depression, and memory impairment. With this in mind, we conducted an experimental study to investigate whether weight-reduction surgery would promote morphological changes in the hippocampal formation, a brain region linked to cognitive and emotional processes. To do so, the present study evaluated the hippocampal expression of parvalbumin interneurons in rats submitted to a gastric restrictive procedure (experimental phytobezoar). Our results demonstrated that rats with gastric-reduced capacity presented a significant increase in the expression of the parvalbumin interneurons in the hippocampal CA1 and CA3 subfields. These data are the first experimental evidence that restrictive bariatric surgery may alter hippocampal cytoarchitecture.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Influência do exercício físico aeróbico na distribuição hipocampal de neurônios imunorreativos a parvalbumina em ratos wistar: um estudo comparativo entre os sexos masculino e feminino
    (Universidade Federal de São Paulo (UNIFESP), 2018-10-25) Placencia, Eduardo Varejao Diaz [UNIFESP]; Silva, Sergio Gomes da [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; http://lattes.cnpq.br/8352745170435172; http://lattes.cnpq.br/9183576123720071; Universidade Federal de São Paulo (UNIFESP)
    Several studies report differences between males and females on physical exerciseinduced brain plasticity, including neurotrophic factor levels, neurogenesis, and navigation strategies in spatial memory task. However, reports in the literature show females are physically more active than males in animal models of physical exercise. With this in mind, we conducted an experimental study to investigate the effect of sex on the brain of rats submitted to same volume and intensity of aerobic exercise. To do so, we evaluated the hippocampal distribution of parvalbumin-containing neurons in male and female rats submitted to 4 weeks of aerobic exercise on a treadmill at 12 m/min, 30 min per day. Parvalbumin is an important calcium binding protein present in gabaergic neurons, furthermore, it has been used as a neuromarker in several studies. Our results show that, in both sexes, physical exercise increased hippocampal density of parvalbumin neurons in the cornus amm onis (CA1, CA2/CA3) and hilus subfields. No difference in exercise-induced hipocampal parvalbumin density was found between male and female rats. These findings suggest that aerobic exercise promotes similar effects on hippocampal distribution of parvalbumin neurons of male and female rats, especially when they are submitted to the same volume and intensity of physical exercise.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Physical exercise during the adolescent period of life increases hippocampal parvalbumin expression
    (Elsevier B.V., 2010-02-01) Silva, Sergio Gomes da [UNIFESP]; Doná, Flávia [UNIFESP]; Silva Fernandes, Maria Jose da [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    In order to investigate whether physical exercise during development would promote changes the calcium-binding protein parvalbumin (PV) expression in the hippocampal formation, we performed an immunostaining Study after an aerobic exercise program in rats during adolescent period of life. Wistar rats were submitted to daily exercise program in a treadmill between postnatal day 21 and 60. Running time and speed were gradually increased during the subsequent days until 18 m/min for 60 min. After the aerobic exercise program, animals of all groups were killed and PV immunostaining procedures were performed. the results showed significant increase of protein level in the hippocampal formation and PV-immunoreactive neurons in CA1 and CA2/CA3 regions of rats submitted to exercise when compared with control rats. This finding indicates that aerobic exercise program during adolescent period promotes neuroplastic changes in hippocampal formation. (C) 2008 Elsevier B.V. All rights reserved.