Navegando por Palavras-chave "Parathormone"
Agora exibindo 1 - 4 de 4
Resultados por página
Opções de Ordenação
- ItemAcesso aberto (Open Access)Baixas concentrações séricas de 25-hidroxivitamina D em crianças e adolescentes com lúpus eritematoso sistêmico(Universidade Federal de São Paulo (UNIFESP), 2011-06-29) Peracchi, Octávio Augusto Bedin [UNIFESP]; Hilário, Maria Odete Esteves [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: to evaluate the levels of 25-hydroxivitamin-D (25(OH)D) in children and adolescents with Systemic Lupus Erythematosus (Juvenile SLE [JSLE]) and to associate them with disease duration and activity, use of medications (chloroquine and glucocorticoids), vitamin D intake, levels of calcium, phosphorus and alkaline phosphatase and bone mineral density. Methods: through a cross-sectional study 30 children and adolescents with SLE were evaluated and compared to 30 healthy individuals age and gender matched. Assessment of clinical status, disease activity, anthropometry, laboratory markers and bone mineral density were performed. Results: of the 30 patients included in the study, 25 (83.3%) were female, 16 (53.3%) caucasians, mean of age of 13.7 years. The mean of age at diagnosis was 10.5 years and the mean of disease duration was 3.4 years. The mean levels of calcium, albumin and alkaline phosphatase were significant lower in the patients with JSLE compared with controls (p<0.001, p=0.006 and p<0.001, respectively). Twenty-nine patients (97%) and 23 controls (77%) had 25(OH)D levels lower than 32 ng/mL with significantly difference between them (p<0.001). Fifteen patients (50%) had vitamin D levels <20 ng/ml and 14 between 20 and 32 ng/ml. However those values were not associated to greater disease activity, higher levels of parathormone, medications or bone mineral density. Vitamin D levels were not different related to ethnic group (p=0.083), body mass index (p=0.955), height to age (p=0.650) and pubertal stage (p=0.524). Conclusions: we observed insufficient serum concentrations of 25(OH)D in patients with JSLE significantly more frequently than in controls, however with no association with disease activity, higher levels of parathormone, use of medications or bone mineral density alterations.
- ItemAcesso aberto (Open Access)Diagnóstico Laboratorial do Hiperparatiroidismo Primário(Sociedade Brasileira de Endocrinologia e Metabologia, 2002-02-01) Hauache, Omar M. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Fleury - Centro de Medicina DiagnósticaPrimary hyperparathyroidism (PHP) is a frequent endocrinopathy. Increased serum calcium levels may be considered as a potential marker for parathyroid autonomy and this explains why PHP should be routinely investigated in whoever presents with hypercalcemia. High or inappropriately normal PTH levels in the presence of hypercalcemia are very suggestive of PHP. On the other hand, PHP is very unlikely in the absence of hypercalcemia. Extracellular calcium concentrations may be evaluated by the measurement of total or ionized calcium, but the serum protein levels do not affect ionized calcium level. Regarding PTH, the current methods available detect the intact molecule of PTH (immunoradiometric and immunochemiluminescent assays), including PTH 1-84 and 7-84. Recently, assays that only detect the so-called bioactive PTH (1-84 PTH) are available. PTH levels are undetectable in humoral hypercalcemia of malignancy. In short, measuring serum calcium and PTH should be enough for the diagnosis of PHP. To further evaluate a patient with PHP and its potential bone and renal complications, one can order other exams such as evaluation of renal function, daily urinary calcium excretion, renal ultrassonography and bone densitometry. These exams may be useful to help the physician decide whether surgery should be indicated or not.
- ItemAcesso aberto (Open Access)Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus(Associação Brasileira de Divulgação Científica, 2014-08-01) Peracchi, Octávio Augusto Bedin [UNIFESP]; Terreri, Maria Teresa Ramos Ascensão [UNIFESP]; Munekata, Regina Viviane [UNIFESP]; Len, Claudio Arnaldo [UNIFESP]; Sarni, Roseli Oselka Saccardo [UNIFESP]; Lazaretti-Castro, Marise [UNIFESP]; Hilário, Maria Odete Esteves [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)We evaluated the concentrations of 25-hydroxyvitamin D [25(OH)D] in children and adolescents with juvenile systemic lupus erythematosus (JSLE) and associated them with disease duration and activity, use of medication (chloroquine and glucocorticoids), vitamin D intake, calcium and alkaline phosphatase levels, and bone mineral density. Thirty patients with JSLE were evaluated and compared to 30 healthy individuals, who were age and gender matched. Assessment was performed of clinical status, disease activity, anthropometry, laboratory markers, and bone mineral density. The 30 patients included 25 (83.3%) females and 16 (53.3%) Caucasians, with a mean age of 13.7 years. The mean age at diagnosis was 10.5 years and mean disease duration was 3.4 years. Mean levels of calcium, albumin, and alkaline phosphatase were significantly lower in patients with JSLE compared with controls (P<0.001, P=0.006, and P<0.001, respectively). Twenty-nine patients (97%) and 23 controls (77%) had 25(OH)D concentrations lower than 32 ng/mL, with significant differences between them (P<0.001). Fifteen patients (50%) had vitamin D levels <20 ng/mL and 14 had vitamin D levels between 20 and 32 ng/mL. However, these values were not associated with greater disease activity, higher levels of parathormone, medication intake, or bone mineral density. Vitamin D concentrations were similar with regard to ethnic group, body mass index, height for age, and pubertal stage. Significantly more frequently than in controls, we observed insufficient serum concentrations of 25(OH)D in patients with JSLE; however, we did not observe any association with disease activity, higher levels of parathormone, lower levels of alkaline phosphatase, use of medications, or bone mineral density alterations.
- ItemSomente MetadadadosSecondary hyperparathyroidism and its relationship with sarcopenia in elderly women(Elsevier B.V., 2015-03-01) Genaro, Patricia de Souza; Pinheiro, Marcelo de Medeiros [UNIFESP]; Szejnfeld, Vera Lucia [UNIFESP]; Martini, Ligia Araujo; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)Low dietary intake of calcium and poor vitamin D status during aging can result in mild secondary hyperparathyroidism, which may be associated with low muscle mass and reduced strength in the elderly. the aim of this study was to investigate whether low vitamin D, high parathormone (PTH), or both, are associated with sarcopenia. A total of 105 women, 35 with sarcopenia and 70 without sarcopenia, were enrolled in the present study. Body composition measurements were performed by DXA and sarcopenia was defined as skeletal muscle mass index < 5.45 kg/m(2) and grip strength lower than 20 kg. Three-day dietary records were taken and adjustments for energy intake made. the estimated average requirement (EAR) method was adopted as a cut-off point for estimating the prevalence of inadequate intake. Serum total calcium, phosphorus, creatinine, intact PTH, and 25(OH) D were measured. Only 1% of the patients met the daily adequate intake for vitamin D and 11% met the daily adequate intake for calcium. Notably, the prevalence of sarcopenia was higher in hyperparathyroidism (25(OH)D < 20 ng/mL and PTH > 65 pg/dL) than in the absence of hyperparathyroidism (41.2 vs 16.2%, respectively; p = 0.046). the odds ratio for sarcopenia in hyperparathyroidism cases was 6.81 (95% CI 1.29-35.9) compared with participants who had low PTH and a high 25(OH) D concentration. the present study showed that vitamin D insufficiency associated with secondary hyperparathyroidism increased the risk of sarcopenia, suggesting that the suppression of hyperparathyroidism by ensuring adequate calcium and vitamin D intake should be considered in interventional studies to confirm potential benefits. (C) 2015 Elsevier Ireland Ltd. All rights reserved.