Navegando por Palavras-chave "Osteoarthrosis"

Agora exibindo 1 - 2 de 2
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Farmacocinética da associação de glucosamina e sulfato de condroitina em humanos sadios do sexo masculino
    (Sociedade Brasileira de Ortopedia e Traumatologia, 2005-01-01) Toffoletto, Odaly; Tavares, Agostinho [UNIFESP]; Casarini, Dulce Elena [UNIFESP]; Redublo, Beata Marie [UNIFESP]; Ribeiro, Artur Beltrame [UNIFESP]; Fundação Oswaldo Ramos Hospital do Rim e Hipertensão; Universidade Federal de São Paulo (UNIFESP)
    Osteoarthrosis is a chronic joint disease that, once patent, leads to a progressive functional disability. As proteochondroitin sulfates are the major contents of the cartilage, it is expected that the ingestion of glucosamine and chondroitin might improve the biological status of that tissue. As we could not find any studies on the pharmacokinetic profile of this association by oral administration route in human beings, the objective of this study was to evaluate it by using the association of glucosamine sulfate (GS) and chondroitin sulfate (CS) given to two groups of twelve healthy male volunteers (group I: one capsule containing 500 mg of GS and 400 mg of CS; group II: four capsules with the same content). Blood samples were collected at pre-determined time intervals up to 48 hours post-dosing. GS and CS were measured in plasma by the DMMB (1,9,dimethyl-dimethilene blue) method. Maximum concentration was achieved within 2 hours (average ± SE; 0.893±0.093 µg/ml, group I; and 2.222±0.313 µg/ml, group II). Areas under curve up to 48 hours were 10.803±0.965 µg-hr/ml and 38.776±2.981 µg-hr/ml for groups I and II, respectively. Both groups showed a second peak after 18 hours, indicating an enterohepatic flow. Our results indicate that this association is absorbed through the oral route by a saturable mechanism, which can enable its use in clinical treatments.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    A multicenter observational study on the role of comorbidities in the recurrent episodes of benign paroxysmal positional vertigo
    (Elsevier B.V., 2014-02-01) De Stefano, Alessandro; Dispenza, Francesco; Suarez, Hamlet; Perez-Fernandez, Nicolas; Manrique-Huarte, Raquel; Ban, Jae Ho; Kim, Min Beom; Strupp, Michael; Feil, Katharina; Oliveira, Carlos A.; Sampaio, Andres L.; Araujo, Mercedes F. S.; Bahmad, Fayez; Gananca, Mauricio M. [UNIFESP]; Gananca, Fernando F. [UNIFESP]; Dorigueto, Ricardo [UNIFESP]; Lee, Hyung; Kulamarva, Gautham; Mathur, Navneet; Di Giovanni, Pamela; Petrucci, Anna Grazia; Staniscia, Tommaso; Citraro, Leonardo; Croce, Adelchi; G dAnnunzio Univ Chieti Pescara; Univ Palermo; British Hosp Montevideo; Univ Navarra; SKKU Univ Seoul; Univ Munich; Universidade de Brasília (UnB); Universidade Federal de São Paulo (UNIFESP); Keimyung Univ; KIMS Hosp Kasaragod; RNT Med Coll Udaipur
    Objective: Primary objective of this study was to find a statistical link between the most worldwide comorbidities affecting the elderly population (hypertension, diabetes, osteoarthrosis, osteoporosis and depression) and recurrent episodes of BPPV. Secondary objective was defining possible groups of risk for people suffering recurrent positional vertigo related to the presence of a well documented comorbidity.Methods: This was an observational, cross-sectional, multicenter, spontaneous, non-pharmacological study. the data of 1092 patients suffering BPPV evaluated in 11 different Departments of Otolaryngology, Otoneurology and Neurology, referring Centers for positional vertigo evaluation, were retrospectively-collected.Results: Regarding evaluated comorbidities (hypertension, diabetes, osteoarthrosis, osteoporosis and depression), data analysis showed the presence of at least one comorbid disorder in 216 subjects (19.8%) and 2 or more in 408 subjects (37.4%). Moreover there was a statistical significant difference between the number of comorbidities and the number of recurrences, otherwise said as comorbidity disorders increased the number of relapses increased too.Conclusion: the presence of a systemic disease may worsen the status of the posterior labyrinth causing a more frequent otolith detachment. This condition increases the risk for patients suffering BPPV to have recurrent episodes, even if correctly managed by repositioning maneuvers. the combination of two or more of aforementioned comorbidities further increases the risk of relapsing BPPV, worsened by the presence of osteoporosis. On the basis of this results it was possible to define groups of risk useful for predicting BPPV recurrence in patients with one or more comorbidity. (C) 2013 Published by Elsevier Ireland Ltd.