Navegando por Palavras-chave "Nevi and melanomas"
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- ItemAcesso aberto (Open Access)Avaliação do efeito da fenitoína (5,5-difenil-2-4- imidazolidione, sódio) na cicatrização cutânea da excisão de nevos melanocíticos na face e no dorso do tórax(Universidade Federal de São Paulo (UNIFESP), 2009-05-25) Pereira, Carlos Augusto Zanardini [UNIFESP]; Alchorne, Alice de Oliveira de Avelar [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)This study aims to evaluate the effect of topical use of phenytoin in healing of skin wounds. A systemic therapy with phenytoin have anticonvulsant activity, and the topical use action is to accelerate the healing of skin wounds. This study evaluated 100 patients each with 2 wounds resulting from excision of lesions of melanocytic nevi, 50 patients with lesions on the face and 50 whith back injuries in the chest, total of 200 lesions excised with punch modified. During treatment the patient received phenytoin to 0.5% in the cream and cream base (control), to make the dressing daily. The follow up of patients was carried out from 7, 14, 21 and 60 days, where the following parameters were evaluated: bleeding, exudate, erythema at the edge of the wound, infection, presence of hypertrophic granulation tissue, healing time, intensity of epithelialization, the wound area, the shape and area of the scar, possible adverse reactions and cosmetic outcome. The patients were compared in age, weight, height, phototype, histological type of lesion. The phenytoin showed better therapeutic and cosmetic results compared with the cream base (control). The phenytoin is a drug of low cost, which accelerates the healing of skin wounds.
- ItemAcesso aberto (Open Access)Dysplastic nevus associated with seborrheic keratosis(Sociedade Brasileira de Dermatologia, 2014-01-01) Botelho, Luciane Francisca Fernandes; Michalany, Nilceo Schwery; Enokihara, Milvia Maria Simoes E Silva; Hirata, Sergio Henrique [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Seborrheic keratosis is a common skin lesion which may coincidentally be associated melanocytic nevi. The authors describe a case of dysplastic nevus associated with seborrheic keratosis and discuss the clinical, dermoscopic, and histological findings of this association. They also discuss the association between seborrheic keratosis and other benign and malignant tumours.
- ItemAcesso aberto (Open Access)Estudo comparativo da flarefotometria em pacientes com melanoma maligno e nevo de coróide(Conselho Brasileiro de Oftalmologia, 2002-01-01) Ballalai, Priscilla Luppi [UNIFESP]; Erwenne, Clélia Maria [UNIFESP]; Chojniak, Martha Motono; Universidade Federal de São Paulo (UNIFESP); Hospital A C Camargo Departamento de Tumores OcularesIntroduction: Malignant intraocular tumors are associated with an increase in the aqueous flare, caused by alterations of the blood-ocular barriers through various mechanisms. Several studies have demonstrated an ocular flare increase using flare photometry in eyes with benign and malignant tumors. Purpose: To evaluate flare photometry as an adjunct method in the differential diagnosis of choroidal malignant melanoma and choroidal nevus comparing to normal control eyes. Methods: Eyes with melanoma and nevus were diagnosed by indirect binocular ophthalmoscopy and/or ultrasound were evaluated. The fellow normal eyes were used as a control. In all subject and control eyes flare photometry was performed using the Laser Flare Meter (FC 500, Kowa), under mydriasis. Statistical analysis was done using the Wilcoxon, Mann-Whitney, and Spearman tests. Results: Thirty-one eyes with malignant melanoma and 18 eyes with nevus were evaluated. The flare photometry average in the eyes with malignant melanoma was 17.1 ph/ms and in the control fellow eyes it was 4.06 ph/ms. In eyes with choroidal nevus the flare photometry average was 6.12 ph/ms and in the control fellow eyes it was 4.47 ph/ms. The flare photometry was higher in eyes with malignant melanoma and nevus than in the fellow normal eyes (p<0.001 and p<0.01). Comparing the eyes with malignant melanoma and nevus, flare photometry was significantly higher in eyes with malignant melanoma (p<0.001). There was a positive correlation between the tumor thickness and flare photometry (r=0.47). Conclusion: Flare photometry is a helpful tool in the differential diagnosis of malignant melanoma and choroidal nevus.
- ItemAcesso aberto (Open Access)Giant congenital melanocytic nevi: 40 years of experience with the serial excision technique(Soc Brasileira Dermatologia, 2017) Mutti, Lais de Abreu [UNIFESP]; Machado Mascarenhas, Marta Regina [UNIFESP]; Goes de Paiva, Joao Marcos [UNIFESP]; Golcman, Ronaldo; Enokihara, Mauro Yoshiaki [UNIFESP]; Golcman, BenjaminAlthough giant congenital melanocytic nevus is a rare lesion, it causes significant deformity and carries a risk of malignant degeneration. Different surgical techniques for the lesion removal are described, including serial resection, resection with skin grafting, and resection and coverage with expanded skin flap (skin expanders). The aim of this study is to report the author's 40 years of experience with cases requiring at least 4 serial excisions to complete the treatment. Serial resection is an effective, safe, and simple technique that requires a lot of patience. Treatment often results in a single linear scar, requires no donor sites, nor large flaps. It is not subject to potencial complications of expanders and avoid aesthetic deformities depending on the location.
- ItemAcesso aberto (Open Access)Melanoma developed during pregnancy - A case report(Sociedade Brasileira de Dermatologia, 2014-01-01) Mestnik, Natalia Cammarosano; Afonso, Joao Paulo Junqueira Magalhaes; Enokihara, Milvia Maria Simoes E Silva; Enokihara, Mauro Yoshiaki; Porro, Adriana Maria [UNIFESP]; Hirata, Sergio Henrique [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)We describe a case of plantar interdigital cutaneous melanoma in a 22-year-old woman who reported changes in a pigmented lesion during pregnancy. Diagnosis was late and evolution unfavourable. The purpose of this report is to draw the attention of dermatologists to the need for careful regular examination of melanocytic lesions in pregnant women, not ignoring possible changes as always physiological.