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    Current advances in targeted therapies for metastatic gastric cancer: improving patient care
    (Future medicine ltd, 2016) Aguiar, Pedro Nazareth, Jr. [UNIFESP]; Muniz, Thiago Pimentel [UNIFESP]; Miranda, Raelson Rodrigues [UNIFESP]; Tadokoro, Hakaru [UNIFESP]; Forones, Nora Manoukian [UNIFESP]; Monteiro, Ines-de-Paula; Castelo-Branco, Pedro; Janjigian, Yelena Y.; de Mello, Ramon Andrade
    In this article, we review the literature on the current advances in targeted therapies for metastatic gastric cancer aimed at improving patient care. We conclude that the key to guiding targeted therapy is individual biomarkers, which are not completely elucidated. HER2 overexpression is the only predictive biomarker currently in use. Furthermore, it is necessary to understand that gastric tumors are heterogeneous