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- ItemSomente MetadadadosChronic hepatosplenic schistosomiasis mansoni: magnetic resonance imaging and magnetic resonance angiography findings(Taylor & Francis Ltd, 2007-03-01) Bezerra, A. S. A.; D'Ippolito, Giuseppe [UNIFESP]; Caldana, R. P.; Cecin, A. O.; Ahmed, M.; Szejnfeld, Jacob [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Beth Israel Deaconess Med CtrPurpose: To evaluate the hepatosplenic manifestations and the portal venous system in patients with chronic infection by Schistosoma mansoni.Material and Methods: A cross-sectional observational study was performed in 28 patients with chronic hepatosplenic schistosomiasis submitted to magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) of the abdomen. Images were interpreted independently by two radiologists to determine the reproducibility of image interpretation and who evaluated the presence of morphological alterations in the liver and spleen, such as hepatosplenomegaly, hepatic fissure widening, periportal fibrosis, and the presence of siderotic nodules. Interobserver and intra-observer agreement were measured with the kappa and intraclass correlation tests. Evaluation of venous collateral pathways and portal and splenic veins was done in consensus by both examiners.Results: Observers identified enlargement of the left lobe (78.5-92.8%) and caudate-to-right-lobe ratio (78.5-92.8%), irregularity of hepatic contours (89.2-96.4%), fissure widening (89.2-100%), and splenic siderotic nodules (84.2%). Splenomegaly, heterogeneity of hepatic parenchyma, peripheral hepatic vessels, and periportal fibrosis were observed in 100% of patients. MRI findings presented almost perfect interobserver (kappa = 0.65-1) and intra-observer (kappa = 0.73-1 for observer 1, and kappa = 0.65-1 for observer 2) agreement for the variables analyzed. MRA showed the presence of collateral pathways in the majority of patients (71.4%) along with widening of portal and splenic veins.Conclusion: Using MRI, hepatosplenic alterations in schistosomiasis are characterized by heterogeneity of hepatic parenchyma, presence of peripheral perihepatic vessels, periportal fibrosis, splenomegaly, siderotic nodules, and the presence of venous collateral pathways.
- ItemSomente MetadadadosFollow-up of endovascular treatment of direct carotid-cavernous fistulas(Springer, 2010-12-01) Pedro Marques, Marcio C. [UNIFESP]; Pereira Caldas, Jose Guilherme M.; Nalli, Darcio R. [UNIFESP]; Fonseca, Jose Roberto F. [UNIFESP]; Nogueira, Roberto G. [UNIFESP]; Abdala, Nitamar [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Direct carotid-cavernous fistula (CCF) is a direct communication between the internal carotid artery (ICA) and the cavernous sinus. Some patients treated with detachable balloons develop pseudoaneurysms or present with a true aneurysm recanalization in the cavernous ICA with poorly known long-term radiological and clinical progression. the objective of the present study was to evaluate the long-term clinical and radiological progression of patients treated with detachable balloons.The present study evaluated 13 patients previously treated for direct CCF by an endovascular approach.The follow-up period ranged between 19 and 128 months. Ophthalmological evaluation demonstrated alterations in eight patients (61.5%). All of these alterations were already present from the moment of the treatment and displayed no signs of progression. Cranial magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) were performed in all patients, and 11 pseudoaneurysms were demonstrated in ten of the 11 patients in whom ICA patency had been preserved. Five patients were submitted for cerebral digital subtraction angiography (DSA) to characterize the pseudoaneurysms previously observed on MRA studies, with no significant differences in morphology, size, aneurismal neck, and number of lesions.Endovascular treatment of direct CCF with detachable balloons has been shown to be a long-term effective and stable therapeutic method. the authors found asymptomatic pseudoaneurysms in 91% of cases where the ICA patency was preserved. MRI and MRA demonstrated an accuracy similar to that of DSA in the diagnosis of pseudoaneurysms of cavernous ICA.