Navegando por Palavras-chave "MICE"

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    Comment on: Performance of the Oxoid MICEvaluator (TM) Strips compared with the Etest (R) assay and BSAC agar dilution
    (Oxford Univ Press, 2011-05-01) Carvalhaes, Cecilia G. [UNIFESP]; Campana, Eloiza H. [UNIFESP]; Barbosa, Paula P. [UNIFESP]; Paula, Ana M.; Gales, Ana C. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Thermo Fisher Sci
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    THE INVOLVEMENT OF THE SYMPATHETIC NERVOUS-SYSTEM IN MEAL-INDUCED THERMOGENESIS IN MICE
    (Stockton Press, 1991-11-01) Griggio, Mauro Antonio [UNIFESP]; Richard, D.; Leblanc, J.; UNIV LAVAL; Universidade Federal de São Paulo (UNIFESP)
    The acute effect of food intake on the activity of the sympathetic nervous system (SNS) in both heart and brown adipose tissue (BAT) was investigated in mice. Upon delivery to the laboratory mice were housed singly and divided into two groups. Half the mice were accustomed to eat their daily food ration in two meals whereas the other half were given continuous access to food. SNS activity in both heart and BAT was estimated by measuring the accumulation of dopamine (DA) after having blocked the transformation of dopamine into noradrenaline (NA) with 1-cyclohexyl-2-mercaptoimidazole (CHMI). CHMI inhibits the enzime dopamine beta-hydroxylase. On the day SNS activity was assessed, continuously fed (CF) or meal-fed (MF) mice were injected with either saline or CHMI one hour before being killed. In order to assess the anticipatory effects of being fed, a group of mice already accustomed to the meal-feeding schedule were not allowed to eat after the injections. Additional CF and MF mice were killed without being injected in order to determine the basal levels of both DA and NA. The results show that the accumulation of DA in both heart and BAT was higher in MF than CF mice regardless of whether MF mice were or were not fed after the injection of CHMI. It therefore appears that the intake of food may increase SNS activity in various tissues in mice, and that such a response may be largely of cephalic origin.
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    PROLONGED TREATMENT WITH CARBAMAZEPINE INCREASES the STIMULATORY EFFECTS of ETHANOL in MICE
    (Elsevier B.V., 1995-07-01) Camarini, R.; Andreatini, R.; Monteiro, M. G.; Universidade Federal de São Paulo (UNIFESP)
    Carbamazepine (CBZ) has been used in the treatment of alcohol withdrawal (AW). However, cases of induction of euphoric feelings when mixed with alcohol have been reported. We verified whether CBZ could potentiate ethanol stimulatory effects in animals. Two groups of mice were injected with saline (group I) or 2 g/kg ethanol (group II) IF, for 20 days. On the next day, each group was divided into two subgroups that received either a single dose of CBZ (10 mg/kg) or vehicle IF, followed, 30 min later, by saline or ethanol injection. Locomotor activity was measured. Acute CBZ did not change locomotor activity of ethanol-treated mice. Treatment with CBZ or vehicle continued for 6 days. Finally, on the 28th day, 30 min after the last CBZ or vehicle injection, an ethanol challenge was given to group II and a saline injection to group I. the results showed a significant potentiation of ethanol stimulatory effects by chronic CBZ treatment. Data indicated that CBZ should be cautiously administered to alcohol-dependent patients.