Navegando por Palavras-chave "Lipid-Peroxidation"

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    Can breast tumors affect the oxidative status of the surrounding environment? A comparative analysis among cancerous breast, mammary adjacent tissue, and plasma
    (Hindawi ltd, 2016) Panis, C.; Victorino, V. J.; Herrera, A. C. S. A.; Cecchini, A. L.; Simao, A. N. C.; Tomita, L. Y. [UNIFESP]; Cecchini, R.
    In this paper, we investigated the oxidative profile of breast tumors in comparison with their normal adjacent breast tissue. Our study indicates that breast tumors present enhanced oxidative/nitrosative stress, with concomitant augmented antioxidant capacity when compared to the adjacent normal breast. These data indicate that breast cancers may be responsible for the induction of a prooxidant environment in the mammary gland, in association with enhanced TNF-alpha and nitric oxide.
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    Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: a comparison with ebselen
    (Funpec-Editora, 2016) Petronilho, Fabricia; Michels, Monique; Danielski, Lucineia G.; Goldim, Mariana Pereira; Florentino, Drielly; Vieira, Andriele; Mendonca, Mariana G.; Tournier, Moema; Piacentini, Barbara; Della Giustina, Amanda; Leffa, Daniela D.; Pereira, Gregorio W. [UNIFESP]; Pereira, Volnei D.; Teixeira Da Rocha, Joao Batista
    Objetive: The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)(2) and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods: The effects of (PhSe)(2) and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results: Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)(2) improved this response. Moreover, the treatment with (PhSe)(2) decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. LB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions: The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)(2) more effective than EB. (C) 2016 Elsevier GmbH. All rights reserved.
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    Omega-3 levels and nicotine dependence: a cross-sectional study and clinical trial
    (Karger, 2016) Zaparoli, Jucara X. [UNIFESP]; Sugawara, Eduardo K. [UNIFESP]; de Souza, Altay A. L. [UNIFESP]; Tufik, Sergio [UNIFESP]; Galduroz, Jose Carlos F. [UNIFESP]
    Background: High oxidative stress, which is caused by smoking, can alter omega-3 fatty acid concentrations. Since omega-3 fatty acids play a role in dopaminergic neurotransmission related to dependence, it is important to understand their effects on nicotine dependence. Methods: This research comprised 2 studies. The first one consisted of a cross-sectional evaluation, in which the levels of the most important omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were compared between smokers and non-smokers in a sample of 171 individuals