Navegando por Palavras-chave "Kinase"

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    Norepinephrine controls effector t cell differentiation through beta 2-adrenergic receptor-mediated inhibition of nf-kappa b and ap-1 in dendritic cells
    (Amer Assoc Immunologists, 2016) Takenaka, Maisa Carla [UNIFESP]; Araujo, Leandro Pires [UNIFESP]; Maricato, Juliana Terzi [UNIFESP]; Nascimento, Vanessa de Mendonça [UNIFESP]; Guereschi, Marcia Grando [UNIFESP]; Rezende, Rafael Machado; Quintana, Francisco J.; Basso, Alexandre Salgado [UNIFESP]
    Despite accumulating evidence indicating that neurotransmitters released by the sympathetic nervous system can modulate the activity of innate immune cells, we still know very little about how norepinephrine impacts signaling pathways in dendritic cells (DC) and the consequence of that in DC-driven T cell differentiation. In this article, we demonstrate that beta(2)-adrenergic receptor (beta(2)AR) activation in LPS-stimulated DC does not impair their ability to promote T cell proliferation
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    Raising the Bar(-seq) in Leishmania genetic screens
    (Cell Press, 2021) Ferreira, Tiago R.; Couñago, Rafael M.; Moretti, Nilmar Silvio [UNIFESP]; http://lattes.cnpq.br/2131472726202687
    Our understanding of regulatory factors in Leishmania differentia- tion has long been restricted by the available genetic tools, but the availability of CRISPR/Cas9 has changed the landscape forever. Recently, Baker and Catta-Preta et al. applied Cas9 editing and kinome-wide bar-seq to dissect the function of 204 kinases in the Leishmania mexicana life cycle.