Navegando por Palavras-chave "Juvenile idiophatic arthritis"

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    Estudo prospectivo de ultrassonografia em pacientes com artrite idiopática juvenil em remissão clínica: a sinovite subclínica pode predizer reativação da doença?
    (Universidade Federal de São Paulo (UNIFESP), 2016-04-14) Silva, Vanessa Bugni Miotto e [UNIFESP]; Terreri, Maria Teresa de Sande e Lemos Ramos Ascensão [UNIFESP]; http://lattes.cnpq.br/2661280959330284; http://lattes.cnpq.br/3834678965714494; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Joint ultrasound (US) studies of patients with juvenile idiopathic arthritis (JIA) in clinical remission demonstrate the presence of subclinical synovitis and positive Power Doppler (PD) signal. The significance of these findings is not yet well understood. Objectives: To assess whether the changes detected by US in a group of patients with JIA in clinical remission can predict disease flare and to evaluate possible factors associated with flare and joint damage over 30 months of follow-up. Methods: Clinical/laboratory assessment: physical examination in 34 joints, functional capacity and inflammatory markers. Sonographic evaluation: synovitis, PD signal and erosion in 34 joints (60 recesses). Subclinical synovitis was defined when there was synovitis and/or positive PD signal in US joints of patients in clinical remission. Flare was defined as any joint presenting arthritis on physical examination requiring therapy modification. Results: Total of 35 patients, 28 (80%) girls, 14 (40%) of the persistent oligoarticular subtype, 12 (34.3%) extended oligoarticular, 9 (25.7%) polyarticular and 26 (74.3%) in remission on medication. At baseline, the mean age of patients was 11.6 ± 3.8 years, the age of JIA onset was 4.4 ± 3.2 years, the disease duration was 7.1 ± 3 5 years, and time of disease remission was 1.9 ± 2.2 years. Of the 35 patients evaluated, 20 (57.1%) flared. There were no clinical or ultrasound differences among patients with and without flare. Regarding the assessment of joint after 6 and 12 months of sonographic evaluation, 70 / 3,162 (2.2%) and 80 / 2,108 (3.8%) of the joints flared, respectively. Joints with subclinical synovitis and positive PD signal flared more after 6 and 12 months. Joint damage (erosion) was evaluated in 2,108 joints and 25 (1.2%) showed erosion over time. Joints with subclinical synovitis showed more erosion. The risk of flare was five times higher in patients with positive PD signal and 14 times higher in patients in remission on medication. Conclusion: The presence of PD signal and remission on medication determined increased risk of JIA flare. Joints with subclinical synovitis and positive signal PD flared more over 12 months and joints with subclinical synovitis presented more erosion over time. Patients in remission on medication and positive PD signal evaluated by US should postpone the reduction or suspension of medication due to the risk of flare. The joints with subclinical synovitis or positive PD signal should be monitored more closely due to the risk of flare and long-term joint damage.
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    Metabolismo lipídico em pacientes com artrite idiopática juvenil dos subtipos poliarticular e sistêmico
    (Universidade Federal de São Paulo (UNIFESP), 2018-03-01) Rodrigues, Wellington Douglas Rocha [UNIFESP]; Terreri, Maria Teresa De Sande E Lemos Ramos Ascensao [UNIFESP]; http://lattes.cnpq.br/2661280959330284; Universidade Federal de São Paulo (UNIFESP)
    Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in the pediatric population. Mortality due to disease activity and secondary infectious complications has decreased, however, this group of patients coexists chronically with the disease and presents, to a greater extent, early negative outcomes such as osteoporosis and late as cardiovascular diseases. Objective: To describe the biomarkers of lipid metabolism related to the cardiovascular risk of children and adolescents with JIA and to relate them to variables of the disease, lipid and glucose profile, nutritional status and food consumption. Methods: Cross-sectional study with 62 patients with JIA. The following were evaluated: disease activity and medications used, body mass index, height for age (z score), skin folds (bicipital, tricipital, subscapular and suprailiac), food consumption (24 hour recall), lipid profile (Total Cholesterol, low density lipoprotein - LDL, high density lipoprotein - HDL and triglycerides - TG and non-HDL), C-reactive protein, erythrocyte sedimentation rate (ESR), apolipoproteins AI and B Paraoxonase (PON). Statistical analysis: Exact Fischer, Chi-square, Mann-Whitney and Spearman correlation tests, p <0.05. Results: The mean duration of the disease was 5 years (± 3.4) and the active disease was observed in 33.9% of the patients. The prevalence of dyslipidemia in general was 62.9% when the lipid profile (CT, LDL-c, HDL-c, non-HDL-c and TG) and 82.3% were evaluated, including apolipoproteins (Apo AI and Apo B) altered. HDL-c and Apo A-I were the most frequent lipid profile changes. The low concentrations of Apo A-I were statistically more frequent in systemic JIA compared to polyarticular. Patients using biological agents showed better adequacy of Apo A-I concentrations. There was no significant correlation between us-CRP and variables related to lipid metabolism. However, HSV showed a negative correlation with Apo A-I levels (r = -0.25, p = 0.047). Conclusion: We conclude that dyslipidemia and alteration of lipid biomarkers are common in patients with JIA. The systemic form and the elevated HSV were associated with lower concentrations of Apo A-I suggesting the participation of the inflammatory process. In addition, the use of biological agents may be a protective factor for dyslipidemia.