Navegando por Palavras-chave "Insulin-like growth factor 2"

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    Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor
    (Biomed Central Ltd, 2016) Mathez, Andreia Latanza Gomes [UNIFESP]; Moroto, Debora [UNIFESP]; Dib, Sergio Atala [UNIFESP]; Sa, Joao Roberto de [UNIFESP]
    A rare sign of some malignant tumors is a sudden eruption of multiple seborrheic keratoses called Leser-Trelat sign. Overproduction of insulin-like growth factor-2 (IGF2) or its precursor is the main mechanism related to non-islet cell tumor hypoglycemia. Doege-Potter syndrome is the name given to paraneoplastic hypoinsulinemic hypoglycemia in presence of a solitary fibrous tumor. This report describes a case of a patient with hypoinsulinemic hypoglycemia and Leser-Trelat sign associated with a malignant solitary fibrous tumor with IGF2 secretion. Both conditions have improved after tumor excision.