Navegando por Palavras-chave "Innervations"

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    Estrogen replacement avoids the decrease of bladder innervations in ovariectomized adult virgin rats: in vivo stereological study
    (Springer, 2009-05-01) Fraga, Rogerio de; Palma, Paulo; Dambros, Miriam [UNIFESP]; Riccetto, Cassio L. Z.; Mandarim-de-Lacerda, Carlos; Miyaoka, Ricardo; Univ Fed Parana; Universidade Estadual de Campinas (UNICAMP); Universidade Federal de São Paulo (UNIFESP); Universidade do Estado do Rio de Janeiro (UERJ)
    The authors quantified the nerve fibers in the bladder wall of ovariectomized rats with and without estradiol replacement.This study was conducted on 40 Wistar rats (3 months old). Group 1: remained intact; Group 2: underwent bilateral ovariectomy, and after 30 days was started on subcutaneous sesame oil replacement (0.2 ml per day) for 90 days; Group 3: sham-operated, and after 30 days was started on subcutaneous sesame oil replacement (0.2 ml per day) for 90 days; Group 4: bilateral ovariectomy, and after 30 days was started on subcutaneous injection of 17 beta-estradiol (10 mu g/kg body weight) for 90 days. S-100 was used to stain nerves myelinized fibers on paraffin rat bladder sections. the G-50 grid system was used to quantitatively analyze the fibers.Long-term estrogen deprivation caused significant changes in bladder innervations, which can be characterized by a decreased number of nerve fibers by 65% (p < 0.001).