Navegando por Palavras-chave "Impaired glucose metabolism"
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- ItemSomente MetadadadosBipolar disorder course, impaired glucose metabolism and antioxidant enzymes activities: A preliminary report(Pergamon-Elsevier Science Ltd, 2016) Mansur, Rodrigo B. [UNIFESP]; Rizzo, Lucas B. [UNIFESP]; Santos, Camila M. [UNIFESP]; Asevedo, Elson [UNIFESP]; Cunha, Graccielle R. [UNIFESP]; Noto, Mariane N. [UNIFESP]; Pedrini, Mariana [UNIFESP]; Zeni-Graiff, Maiara [UNIFESP]; Gouvea, Eduardo S.; Cordeiro, Quirino; Reininghaus, Eva Z.; McIntyre, Roger S.; Brietzke, Elisa [UNIFESP]This study aimed to examine the role of oxidative stress in bipolar disorder (BD) by evaluating the relationship among antioxidant enzymes activities, impaired glucose metabolism (IGM) and illness course. We measured the activities of plasma superoxide dismutase (SOD) and glutathione peroxidase (GPx) in individuals with BD (N = 55) and healthy controls (N = 28). Information related to current and past psychiatric/medical history, as well as prescription of any pharmacological treatments was captured. Impaired glucose metabolism was operationalized as pre-diabetes or type 2 diabetes mellitus. Our results showed that, after adjustment for age, gender, alcohol use, smoking and current medication, both BD (p < 0.001) and IGM (p = 0.019) were associated with increased GPx activity, whereas only BD was associated with decreased SOD activity (p = 0.008). We also observed an interaction between BD and IGM on SOD activity (p = 0.017), whereas the difference between BD and controls was only significant in individuals with IGM (p = 0.009). IGM, GPx and SOD activity were independently associated with variables of illness course. Moreover, IGM moderated the association between SOD activity and number of mood episodes (p < 0.001), as a positive correlation between SOD activity and mood episodes was observed only in participants with IGM. In conclusion, BD and IGM are associated with independent and synergistic effects on markers of oxidative stress. The foregoing observations suggest that the heterogeneity observed in previous studies evaluating antioxidant enzymes in BD may be a function of concurrent IGM
- ItemSomente MetadadadosImpaired glucose metabolism moderates the course of illness in bipolar disorder(Elsevier Science Bv, 2016) Mansur, Rodrigo Barbachan [UNIFESP]; Rizzo, Lucas Bortolotto [UNIFESP]; Santos, Camila Mauricio [UNIFESP]; Asevedo, Elson [UNIFESP]; Cunha, Graccielle Rodrigues da [UNIFESP]; Noto, Mariane Nunes [UNIFESP]; Pedrini, Mariana [UNIFESP]; Zeni, Maiara [UNIFESP]; Cordeiro, Quirino [UNIFESP]; McIntyre, Roger S.; Brietzke, Elisa [UNIFESP]Background: The longitudinal course of bipolar disorder (BD) is highly heterogeneous, and is moderated by the presence of general medical comorbidities. This study aimed to investigate the moderating effects of impaired glucose metabolism (IGM) on variables of illness course and severity in a BD population. Methods: Fifty-five patients with BD were evaluated. All subjects were evaluated with respect to current and past psychiatric and medical disorders, as well as lifetime use of any medication. Body mass index (BMI) and metabolic parameters were obtained. IGM was operationalized as pre-diabetes or type 2 diabetes mellitus. Results: Thirty (54.5%) individuals had IGM. After adjustment for age, gender, ethnicity, alcohol use, smoking, BMI and past and current exposure to psychotropic medications, individuals with IGM, when compared to euglycemic participants, had an earlier age of onset (RR: 0.835, p=0.024), longer illness duration (RR: 1.754, p=0.007), a higher number of previous manic/hypomanic episodes (RR: 1.483, p=0.002) and a higher ratio of manic/hypomanic to depressive episodes (RR: 1.753, p=0.028). Moreover, we observed a moderating effect of IGM on the association between number of mood episodes and other variables of illness course, with the correlation between lifetime mood episodes and frequency of episodes being significantly greater in the IGM subgroup (RR: 1.027, p=0.029). All associations observed herein remained significant after adjusting for relevant confounding factors (e.g. age, alcohol and tobacco use, exposure to psychotropic agents, BMI). Limitations: Cross-sectional design, small sample size. Conclusions: Comorbid IGM may be a key moderator of illness progression in BD. (C) 2016 Elsevier B.V. All rights reserved.