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- ItemAcesso aberto (Open Access)Optimizing bronchodilation in the prevention of COPD exacerbations(Biomed Central Ltd, 2017) Miravitlles, Marc; Anzueto, Antonio; Jardim, Jose R. [UNIFESP]The natural disease course of chronic obstructive pulmonary disease (COPD) is often punctuated by exacerbations: acute events of symptom worsening associated with significant morbidity and healthcare resource utilization