Navegando por Palavras-chave "Hypothalamic-pituitary-adrenal axis"
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- ItemSomente MetadadadosFactors related to the cortisol awakening response of children working on the streets and siblings, before and after 2 years of a psychosocial intervention(Elsevier B.V., 2015-02-01) Mello, Andrea Feijo [UNIFESP]; Juruena, Mario Francisco; Maciel, Mariana Range [UNIFESP]; Cavalcante-Nobrega, Luciana Porto [UNIFESP]; Cividanes, Giuliana Claudia [UNIFESP]; Fossaluza, Victor; Calsavara, Vinicius; Mello, Marcelo Feijo [UNIFESP]; Cleare, Anthony James; Mari, Jair de Jesus [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Kings Coll LondonThe study objective was to observe the cortisol awakening response (CAR) pattern before and after a psychosocial intervention with children from dysfunctional families who had at least one child working on the streets, and to verify factors related to it. Two hundred and eleven children between 7 and 14 years old were selected and 191 were included, 178 were re-evaluated 2 years after, of whom 113 had cortisol measures completed. Besides cortisol, they were evaluated at baseline and at end point regarding: abuse/neglect, mental health symptoms, exposure to urban violence and family environment. There was no significant difference between the CAR area under the curve (AUC) before and after the intervention. Two regression analysis models were built to evaluate factors related to the CAR before and after intervention. Before the intervention, working on the streets (vs. not) was related to a greater cortisol increase after awakening, at follow-up, having suffered physical punishment (vs. not) was related to a flattened cortisol response. the intervention was not associated with changes in the magnitude of the CAR AUC, though the CAR was associated with psychosocial stressors pre- and post-intervention. Effective interventions for children at risk that might shape a physiological cortisol response are still needed. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
- ItemSomente MetadadadosMaternal Immune Activation Increases the Corticosterone Response to Acute Stress without Affecting the Hypothalamic Monoamine Content and Sleep Patterns in Male Mice Offspring(Karger, 2014-01-01) Zager, Adriano; Andersen, Monica L. [UNIFESP]; Tufik, Sergio [UNIFESP]; Palermo-Neto, Joao; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)Background/Aims: Early life experiences are homeostatic determinants for adult organisms. We evaluated the impact of prenatal immune activation during late gestation on the neuroimmune-endocrine function of adult offspring and its interaction with acute stress. Methods: Pregnant Swiss mice received saline or lipopolysaccharide (LPS) on gestational day 17. Adult male offspring were assigned to the control or restraint stress condition. We analyzed plasmatic corticosterone and catecholamine levels, the monoamine content in the hypothalamus, striatum and frontal cortex, and the sleep-wake cycle before and after acute restraint stress. Results and Conclusion:Offspring from LPS-treated dams had increased baseline norepinephrine levels and potentiated corticosterone secretion after the acute stressor, and no effect was observed on hypothalamic monoamine content or sleep behavior. the offspring of immune-activated dams exhibited impairments in stress-induced serotonergic and dopaminergic alterations in the striatum and frontal cortex. the data demonstrate a distinction between the plasmatic levels of corticosterone in response to acute stress and the hypothalamic monoamine content and sleep patterns. We provide new evidence regarding the influence of immune activation during late gestation on the neuroendocrine homeostasis of offspring. (C) 2013 S. Karger AG, Basel
- ItemAcesso aberto (Open Access)Repercussões imunológicas dos distúrbios do sono: o eixo hipotálamo-pituitária-adrenal como fator modulador(Associação Brasileira de Psiquiatria - ABP, 2007-05-01) Palma, Beatriz Duarte [UNIFESP]; Tiba, Paula Ayako [UNIFESP]; Machado, Ricardo Borges [UNIFESP]; Tufik, Sergio [UNIFESP]; Suchecki, Deborah [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: To review the literature on the interaction between sleep and the immune system. METHOD: A search on Web of Science and Pubmed database including the keywords sleep, sleep deprivation, stress, hypothalamic-pituitary-adrenal axis, immune system, and autoimmune diseases. RESULTS: On Web of Science, 588 publications were retrieved; 61 references, more significant and closer to our objective, were used, including original articles and review papers. CONCLUSION: Sleep deprivation and immune system exert a bidirectional influence on each other. Since sleep deprivation is considered a stressor, inasmuch as it induces elevation of cortisol or corticosterone levels in humans and rodents, respectively, and given the well-known immunosuppressive effect of glucocorticoids, we propose that increased activation of the hypothalamic-pituitary-adrenal axis is a major mediator of the immune alterations observed in patients with insomnia or in sleep deprived subjects.
- ItemAcesso aberto (Open Access)Vulnerabilidade e Resiliência ao Estresse: Aspectos ontogenéticos das consequências comportamentais, neuroendócrinas e neuroquímicas(Universidade Federal de São Paulo (UNIFESP), 2013) Suchecki, Deborah [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)This Full Professorship thesis portrays a current and frequently present matter in human daily life, Stress. By means of a broad literature overview, I intend to present the biological foundation of the hormonal and behavioural responses to stressful stimuli throughout life span, with an emphasis in my work. The complete, yet unpublished studies are presented and discussed in the present document. The findings show that outcomes of stressful events depend on the stimulus features and on individual characteristics. Therefore, recruitment of the response systems has the purpose of giving support to necessary and appropriate behaviours for a given situation. However, to be perceived as a stressor, the stimulus must be uncontrollable and unpredictable. As for the individual, coping strategies are of utmost importance and may determine, together with one’s previous history, the success or failure to deal with adverse situations, especially when they are prolonged.