Navegando por Palavras-chave "Hypothalamic inflammation"

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    Efeito do tratamento com Ginkgo biloba sobre a inflamação hipotalâmica presente em ratos com obesidade induzida pela dieta
    (Universidade Federal de São Paulo, 2015-11-27) Julio, Viviane da Silva [UNIFESP]; Telles, Monica Marques [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    It has been described that treatment with the standardized extract of Ginkgo biloba (EGb) promotes improvement of inflammatory conditions and this effect arises through inhibition of the Toll-like receptors. It is known that elevated circulating levels of saturated fatty acids that activates inflammatory pathway through the Toll-like receptor 4, promoting the expression of proinflammatory cytokines involved in obesity, such as hypothalamic inflammation. Therefore, the aim of this study was to analyze the effect of EGb on pathways of Toll-like receptor 4, serotonergic and hypothalamic neuropeptides of diet induced obesity (DIO) rats. The results showed no effect of EGb on the approaches. However, we observed in the EGb treated group a reduction in cumulative food consumption trend and a significant reduction in the total body weight gain over the period of treatment and in the mass of the retroperitoneal fat depot. Furthermore, the 5-HT1B levels and AgRP gene expression showed a decreasing trend in rats treated with EGb, these data could explain at least in part the reduced food intake observed in this study. The results regarding the reduction of body weight and visceral fat mass in obese animals, even maintaining high fat and high calorie diet during the herbal treatment, allow us to suggest that EGb represent an alternative therapy to prevent and / or treat obese people who have difficulties in getting used to a healthy diet and physical exercise. Therefore, it is necessary to elucidate the mechanisms of action of this herbal medicine on energy homeostasis.
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    Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappa Bp65 signaling in adult offspring
    (Elsevier B.V., 2012-03-01) Pimentel, Gustavo Duarte [UNIFESP]; Lira, Fabio Santos de [UNIFESP]; Rosa, Jose Cesar [UNIFESP]; Oliveira, Juliana Lopez de [UNIFESP]; Hachul, Ana Claudia Losinskas [UNIFESP]; Souza, Gabriel Inacio Honorato de [UNIFESP]; Carmo, Maria das Gracas Tavares do; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Tufik, Sergio [UNIFESP]; Seelaender, Marilia [UNIFESP]; Oyama, Lila Missae [UNIFESP]; Nascimento, Claudia Maria da Penha Oller do [UNIFESP]; Watanabe, Regina Lucia Harumi [UNIFESP]; Ribeiro, Eliane Beraldi [UNIFESP]; Pisani, Luciana Pellegrini [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio de Janeiro (UFRJ)
    We examined whether feeding pregnant and lactating rats with hydrogenated vegetable fats rich in trans fatty acids led to an increase in serum endotoxin levels and inflammation and to impaired satiety-sensing pathways in the hypothalamus of 90-day-old offspring. Pregnant and lactating Wistar rats were fed either a standard chow (Control) or one enriched with hydrogenated vegetable fat (Trans). Upon weaning, the male offspring were divided in two groups: Control-Control (CC), mothers and offspring fed the control diet; and Trans-Control (TC), mothers fed the trans diet, and offspring fed the control diet the offspring's food intake and body weight were quantified weekly and the offspring were killed on the 90th day of life by decapitation. the blood and hypothalamus were collected from the offspring. Food intake and body weight were higher in the TC rats than in the CC rats. TC rats had increased serum endotoxin levels and increased hypothalamic cytokines, IL-6, TNF-alpha and IL1-beta, concentrations (P<.05). TLR4, NF kappa Bp65 and MyD88 were higher (P <.05) in the TC rats than in the CC rats. AdipoR1 was lower in the TC rats than in the CC rats. Thus, the present study shows that the mothers' hydrogenated vegetable fat intake during pregnancy and lactation led to hypothalamic inflammation and impaired satiety-sensing, which promotes deleterious metabolic consequences such as obesity, even after the withdrawal of the causal factor. in other words, the effect remains after the consumption of the standard chow by offspring. (C) 2012 Elsevier Inc. All rights reserved.