Navegando por Palavras-chave "Human Papillomavirus"
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- ItemSomente MetadadadosExpression of human papillomavirus e6 and e7 oncoprotein mrna in women with low-grade squamous intraepithelial lesions or less(Funpec-editora, 2016) Casagrande, D. C. [UNIFESP]; Ribalta, J. C. L. [UNIFESP]; Leite, K. D. P. F. [UNIFESP]; Schimidt, M. [UNIFESP]; Speck, N. M. D. G. [UNIFESP]We verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. To investigate the relationship between mRNA expression and viral infection type, we assessed genotyping in single infections. Samples from 825 women were submitted to the E6/E7 survey. We noticed a larger percentage of E6/E7 mRNA expression in the atypical squamous cells of undetermined significance (ASC-US) and LSIL cytologies. Negative results of mRNA expression were in accordance with negative cytologies. In positive cases, the infection by a single HPV type was most common, with type 16 being most prevalent. The expression of mRNA was most prevalent in ASC-US and LSIL cytologies, compared with the negative cytology. The infection by a HPV type was more frequent in cases of positive expression, with HPV type 16 being found most frequently. Patients with LSIL cytologies had a higher percentage of multiple infections.
- ItemSomente MetadadadosHpv genotyping and p16 expression in xingu indigenous park, brazil(Univ Fed Sao Carlos, Dept Engenharia Materials, 2016) Freitas, V. G. [UNIFESP]; Focchi, G. R. [UNIFESP]; Pereira, E. R. [UNIFESP]; Levi, J. E.; Speck, N. M. G. [UNIFESP]; Ribalta, J. C. [UNIFESP]The association between high-risk human papillomavirus (HPV) genotypes and p16 expression in indigenous women from the Xingu Indigenous Park, Brazil, was unknown. This study evaluated p16 expression in women with a histological diagnosis of cervical intraepithelial neoplasia (CIN) 3 or higher and correlated this expression with HPV genotypes to determine possible discrepancies in the expression of this marker. We evaluated 37 previously collected samples with different HPV genotypes and high-grade lesions diagnosed based on cytology, histology, and colposcopy. Immunohistochemical analysis was performed using paraffin-embedded tissue sections and the CINtec (R) Histology Kit. p16 protein expression was investigated by immunostaining with an anti-p16 antibody. HPV genotyping was performed by reverse hybridization. The age of the study population ranged from 22-75 years (43.81 +/- 15.89 years) and parity ranged from 1-11 (5.92 +/- 2.58). Thirteen different HPV genotypes were found using the INNO-LiPA kit. Single and multiple infections by HPV were found with prevalence of single infections (P = 0.029). Comparison between HPV genotype and simple or multiple infections was highly significant
- ItemAcesso aberto (Open Access)Papilomavírus humano (HPV) entre jovens: um sinal de alerta(Faculdade de Saúde Pública, Universidade de São Paulo.Associação Paulista de Saúde Pública., 2013-03-01) Costa, Larissa Aparecida [UNIFESP]; Goldenberg, Paulete [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Human Papillomavirus (HPV) assumes an important focus in public health care mainly because recognition of its association with cancer, especially cervix cancer. The purpose of this study was to characterize the level of knowledge about HPV infection and preventive practices among youths, with intention to support health care protocols. Descriptive data collection enrolled a self-completion questionnaire, addressed to first and third year health care college students of Campus Baixada Santista of Federal University of São Paulo - UNIFESP. With age of sexual initiation concentrated between 15 and 17 years old, respondents referred use of preventive methods during the first sexual relation firstly associated to concern about pregnancy and followed by Sexually Transmitted Disease - STD prevention. Restrict knowledge about HPV was referred by the students. Although acquaintance of HPV increased from the first year to the third year, incomprehension was shown regarding its transmission, consequences or prevention. This survey revealed the need for available information regarding characteristics of HPV disease.
- ItemAcesso aberto (Open Access)Prevalência de HIV, papilomavírus humano e sífilis na Penitenciária Feminina da Capital, São Paulo, 1997-1998(Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, 2001-12-01) Lopes, Fernanda; Latorre, Maria Do Rosário Dias De Oliveira; Pignatari, Antonio Carlos Campos [UNIFESP]; Buchalla, Cassia Maria; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)Incarcerated women as a group are particularly vulnerable to infections. The lack of public programs for prevention, early diagnosis, and treatment contribute to the increase in the incidence and prevalence of diseases in general and especially sexually transmitted diseases. This article aims to estimate the prevalence of infection by the human immunodeficiency virus (HIV), human papillomavirus (HPV), and syphilis among inmates at the Women's Penitentiary in the State capital of São Paulo, Brazil. All inmates were invited to participate in the study, which was divided into two stages: 1. STD/AIDS preventive workshops including interviews and 2. laboratory tests. The interview covered knowledge of STD/AIDS, risk behavior, and individual reproductive health history. A total of 262 women, with a mean age of 32.4 years and limited schooling, participated in more than one stage of the study. Prevalence rates were 14.5% for HIV, 16.3% for high-oncogenic-risk HPV probes, 4.8% for low-oncogenic-risk HPV probes, and 5.7% for syphilis. The authors conclude that STD/HIV constitute a serious health problem in the prison system, requiring urgent preventive measures.