Navegando por Palavras-chave "Her2"

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    Carcinoma Mamário Invasivo Her2-Superexpresso E Triplo-Negativo: Correlação Entre Achados De Imagem E Subtipos Imunohistoquímicos
    (Universidade Federal de São Paulo (UNIFESP), 2017-11-30) Santiago, Isaac Bispo [UNIFESP]; Fernandes, Artur Da Rocha Correa [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: To evaluate the epidemiological, anatomopathological and imaging characteristics of the different modalities of invasive mammary tumors of HER2-superexpressed and triple-negative molecular subtypes from a database of biopsies performed at two breast imaging centers. Methods: Retrospective study descriptive study with 26 patients submitted to percutaneous breast biopsy in two mammary imaging centers, with histopathological result of invasive mammary carcinoma and immunohistochemical pattern compatible with HER2-superexpressed and triple-negative subtypes, from 2010 to 2015, correlating the immunohistochemical pattern with the occurrence of imaging findings, epidemiological and histopathological. RESULTS: Twenty-six cases were found: 18 triple-negative tumors and 8 HER-2 superexpressed tumors. The mean age for TN tumors was 48.8 years and for HER-2 it was 50 years. Ductal carcinoma was the most common histological subtype in TN tumors (94.5%) and HER2 (87.5%), presenting nuclear grade III in 94.5% of TN tumors and 75% in HER2-superexpressed tumors. At mammography, 81.6% of TN tumors and 66.6% of HER2 presented as nodules / mass. In the sonographic study, the non-circumscribed masses predominated (86.6% in TN, 100% in HER2). Two cases (13.4%) of circumscribed nodules were found in the NT group. At MRI, there was predominance of nodular enhancement in 70% of NT, with a more common pattern of heterogeneous enhancement (58%). CONCLUSION: Tumor tumors TN present greater manifestation as non-calcified, non-circumscribed mass, with heterogeneous enhancement, while HER-2 tumors present a larger manifestation as irregular and non-circumscribed mass, with significantly larger tumor dimensions in relation to TN tumors.