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    Gut-central nervous system axis is a target for nutritional therapies
    (Biomed Central Ltd, 2012-04-10) Pimentel, Gustavo Duarte [UNIFESP]; Micheletti, Thayana O.; Pace, Fernanda; Rosa Neto, José Cesar [UNIFESP]; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Lira, Fabio Santos de [UNIFESP]; Universidade Estadual de Campinas (UNICAMP); Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Univ So Santa Catarina UNESC; Jose Caetano de Lima
    Historically, in the 1950s, the chemist Linus Pauling established a relationship between decreased longevity and obesity. At this time, with the advent of studies involving the mechanisms that modulate appetite control, some researchers observed that the hypothalamus is the appetite centre and that peripheral tissues have important roles in the modulation of gut inflammatory processes and levels of hormones that control food intake. Likewise, the advances of physiological and molecular mechanisms for patients with obesity, type 2 diabetes mellitus, inflammatory bowel diseases, bariatric surgery and anorexia-associated diseases has been greatly appreciated by nutritionists. Therefore, this review highlights the relationship between the gut-central nervous system axis and targets for nutritional therapies.