Navegando por Palavras-chave "Growth factor"

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    Crema para la piel con factor de crecimiento epidermico oligopéptido -1
    (Universidade Federal de São Paulo (UNIFESP), 2017-10-09) Medina Mendonza, Maira Eugenia [UNIFESP]; Ferreira, Lydia Masako [UNIFESP]; Blanes, Leila [UNIFESP]; http://lattes.cnpq.br/1898450330418640; http://lattes.cnpq.br/1619822351741819; http://lattes.cnpq.br/2191877318404296; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Over time the skin loses firmness and elasticity due to the loss of not only collagen and elastin, but also epidermal growth factor. For this reason in the present study it was proposed to develop a skin cream where the epidermal growth factor is the active principle. Objective: to develop a skin cream with Epidermal Growth Factor (EGF) Oligopeptide1. Method: Exploratory and descriptive investigation whose search was carried out in the databases Pubmed, Scielo, National Institute of Industrial Property (INPI), Espacenet, Wipo and Google Patents. The cream has been manipulated from the active principle, the epidermal growth factor olipéptico-1. Next, preliminary tests of thermal and accelerated and microbiological stability of the cream were performed to recognize and analyze the factors that could accelerate or delay alterations in these parameters. Results: Four patents were found where FCE was used for tissue regeneration, but none was used as the only active ingredient to counteract signs of skin aging. Preliminary study approved the formula in terms of appearance, odor and volume, within the product considered cosmetic and was determined pH of 5.67 and density of 1.0483g / ml. A skin cream with FCE Oligopeptide-1, white viscose, free of lumps, was then made with Polybase CT-20%; Octyl Palmitate - 5%; Softisan 649-5%; Glycerin - 2%; Cetiol 868-2%; Edta - 0.2%; Henoxetol -1%; BHT - 0.05%; Flower Essence of Plum - 1%; Nano Water osmosis qsp - 60ml and FCE - 3%. Physical-chemical, organoleptic and microbiological stability tests were appropriated and approved. Conclusion: A skin cream with FCE oligopéptido-1 has been developed.
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    Envolvimento das proteínas fosforiladas no resíduo de tirosina no hipocampo de ratos submetidos ao status epilepticus induzido por pilocarpina
    (Universidade Federal de São Paulo (UNIFESP), 2016-02-06) Castro Neto, Eduardo Ferreira de [UNIFESP]; Mazzacoratti, Maria da Graca Naffah [UNIFESP]; http://lattes.cnpq.br/3202325307358102; http://lattes.cnpq.br/8245651230799195; Universidade Federal de São Paulo (UNIFESP)
    Protein phosphorylation on tyrosine residue has been associated with different pathologies in the nervous system, including temporal lobe epilepsy. Objective: The objective of this work was to identify the phosphotyrosine proteins involved in status epilepticus (SE) onset/maintenance and those linked to SE resistance in animals submitted to pilocarpine-induced epilepsy. Method: Three groups of animals were studied: SE Group (rats with 5 h of SE, n-=5); PSS group (pilocarpine-injected animals that did not develop SE, n=5) and Control Group (saline-treated rats, n=5). The hippocampi were isolated and submitted to proarray kit, (Full Moon BioSystems, Inc.) containing specific antibodies to identify 228 phosphoproteins. Data were analyzed using ANOVA and Tukey- Kramer as post-test and p ? 0.05 was accepted. Results: One hundred twenty three out of 228 phosphoproteins presented significant altered levels among groups. From these 123 phosphoproteins, 36 attracted our attention due to their important particularities, that is, 18 presented increased phosphorylation compared to control and non-SE groups, 12 from non-SE group displayed significant differences when compared to control and SE groups and 6 presented altered levels among all groups. Conclusion: In this study we identified proteins that are probably linked to the generation of SE from those linked to the SE resistance. Knowing pathways involved in epileptogenesis may help to understand the mechanisms responsible for different vulnerabilities to long-lasting seizures.