Navegando por Palavras-chave "Fatty acid"
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- ItemSomente MetadadadosChia (Salvia hispanica L.) flour promotes beneficial effects on adipose tissue but not on glycaemic profile of diet-induced obesity in mice(Wiley, 2017) Carnier, June [UNIFESP]; Silva, Fernanda Pinheiro da [UNIFESP]; Miranda, Danielle Araujo de [UNIFESP]; Santamarina, Aline Boveto [UNIFESP]; Mennitti, Lais Vales [UNIFESP]; Moreira, Renata Guimaraes; Nascimento, Claudia Maria da Penha Oller do [UNIFESP]; Ribeiro, Eliane Beraldi [UNIFESP]; Oyama, Lila Missae [UNIFESP]This study evaluated effects of integral chia flour (Salvia hispanica L.) associated with high‐fat diet on glucose metabolism, fatty acid profile, and inflammatory mediators in epididymal adipose and liver tissue using experimental obesity models induced by high‐calorie and ‐fat diets. Forty‐eight mice were divided into four experimental groups: control diet (C); control diet + chia flour (CCh); high‐fat and ‐calorie diet (H), and high‐fat and ‐calorie diet + chia flour (HCh). Tissue cytokines, fatty acid profile, and glycaemic profile were measured. In oral glucose tolerance testing, HCh presented higher glycaemia than H at 15, 30, and 120 min. In epididymal adipose tissue, CCh showed higher accumulation of alpha‐linolenic fatty acid (α‐LNA) than C, while HCh showed higher accumulation of α‐LNA and lower concentrations of C20:4n6 fatty acid than H. In liver tissue, CCh presented higher accumulation of α‐LNA and lower concentrations of C20:4n6 fatty acid than C. We believe that 12 g of chia flour per kg of food for 10 wk is essential for prevention and treatment of obesity; however, it may be necessary to adjust chia amounts and treatment times to improve glycaemic profiles. This study provides pioneering results on the effects of chia in mice. Practical applications: With the hope of losing weight and becoming healthier, many people adopt radical diets that can be harmful to their health. Accordingly, dietary guidelines must be carefully planned by qualified health professionals, especially considering the comorbidities of diabetes and cardiovascular disease that accompany obesity. In addition, the adequate treatment of obesity increases the chances of the patients maintaining their diet and lifestyle changes, thus, allowing for greater control of their obesity. Consequently, knowledge of the appropriate dosages and effects of chia is important for the development of new tools for composing dietary guidelines for healthy individuals, especially for the treatment of obese patients.
- ItemSomente MetadadadosFish oil attenuates methylmalonate-induced seizures(Elsevier B.V., 2013-07-01) Reschke Bandero, Cristina Ruedell; Salvadori, Mirian G. S. S.; Gomes, Anajara Teixeira; Dal Ri, Nadja M. K.; Furian, Ana Flavia; Oliveira, Mauro Schneider; Rambo, Leonardo Magno; Scorza, Fulvio A. [UNIFESP]; Cysneiros, Roberta M.; Emanuelli, Tatiana; Mello, Carlos Fernando; Universidade Federal de Sergipe (UFS); Universidade Federal de São Paulo (UNIFESP); Univ Presbiteriana MackenzieMethylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurological dysfunction, including seizures. Dietary fatty acids are known as an important energy source and reduce seizure activity in selected acute animal models. This study investigated whether chronic treatment with fish oil or with oleic acid attenuates MMA-induced seizures and whether maintenance of Na+,K+-ATPase activity was involved in such an effect. Adult male Wistar rats were given fish oil (85 mg/kg), oleic acid (85 mg/kg) or vehicle (0.42% aqueous Cremophor EL (TM), 4 mL/kg/body weight/day), p.o., for 75 days. On the 73th day a cannula was implanted in the right lateral ventricle with electrodes over the parietal cortex for EEG recording. On the 76th day the animals were injected with NaCl (2.5 mu Lmol/2.5 mu L, i.c.v.), or with MMA (2.5 mu mol/2.5 mu L, i.c.v.), and seizure activity was measured by electroencephagraphic (EEG) recording with concomitant behavior monitoring. the effect of prostaglandin E-2 (PGE(2)) on Na+,K+-ATPase activity of slices of cerebral cortex from NaCl-injected animals was determined. Fish oil increased the latency to MMA-induced tonic-clonic seizures, reduced the mean amplitude of ictal EEG recordings, and prevented PGE(2)-induced decrease of Na+,K+-ATPase activity in cortical slices in vitro. Oleic acid decreased mean amplitude of ictal EEG recordings. the results support that fish oil decreases MMA-induced seizures. the decreased sensitivity of Na+,K+-ATPase to the inhibitory effect of PGE(2) in fish oil-treated animals may be related to the currently reported anticonvulsant activity. (C) 2013 Elsevier B.V. All rights reserved.
- ItemSomente MetadadadosLangmuir-Blodgett films based on poly(p-phenylene vinylene) and protein-stabilised palladium nanoparticles: Implications in luminescent and conducting properties(Elsevier B.V., 2013-07-01) Goto, Thiago E. [UNIFESP]; Sakai, Andrei [UNIFESP]; Iost, Rodrigo M.; Silva, Welter C.; Crespilho, Frank N.; Peres, Laura O. [UNIFESP]; Caseli, Luciano [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Univ Fed PiauiIn this paper, poly(p-phenylene vinylene) block copolymers (PPV) were immobilised in stearic acid (HSt) Langmuir-Blodgett (LB) films, and their conducting and luminescent properties were enhanced by the incorporation of palladium nanoparticles stabilised by glucose oxidase (GOx-PdNPs). the nanobiocomposite, based on HSt, PPV, and GOx-PdNPs, was transferred from the air-water interface onto solid supports using the LB technique. the films were characterised by surface pressure-area isotherms, polarisation modulation infrared reflection-absorption spectroscopy, fluorescence spectroscopy, and conductivity measurements. the results indicated that the incorporation of GOx-PdNPs in PPV-HSt LB films enhances the luminescence and conducting properties of the PPV. Based on the higher conductivity and emission obtained with the hybrid LB films and the ability to tune the molecular-level interactions between the film components by changing the experimental conditions, thus allowing for further optimisation, one may envisage applications for these films in optical and electronic devices, such as organic light-emitting diodes. (C) 2013 Elsevier B.V. All rights reserved.