Navegando por Palavras-chave "Fator de crescimento"

Agora exibindo 1 - 1 de 1
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Crema para la piel con factor de crecimiento epidermico oligopéptido -1
    (Universidade Federal de São Paulo (UNIFESP), 2017-10-09) Medina Mendonza, Maira Eugenia [UNIFESP]; Ferreira, Lydia Masako [UNIFESP]; Blanes, Leila [UNIFESP]; http://lattes.cnpq.br/1898450330418640; http://lattes.cnpq.br/1619822351741819; http://lattes.cnpq.br/2191877318404296; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Over time the skin loses firmness and elasticity due to the loss of not only collagen and elastin, but also epidermal growth factor. For this reason in the present study it was proposed to develop a skin cream where the epidermal growth factor is the active principle. Objective: to develop a skin cream with Epidermal Growth Factor (EGF) Oligopeptide1. Method: Exploratory and descriptive investigation whose search was carried out in the databases Pubmed, Scielo, National Institute of Industrial Property (INPI), Espacenet, Wipo and Google Patents. The cream has been manipulated from the active principle, the epidermal growth factor olipéptico-1. Next, preliminary tests of thermal and accelerated and microbiological stability of the cream were performed to recognize and analyze the factors that could accelerate or delay alterations in these parameters. Results: Four patents were found where FCE was used for tissue regeneration, but none was used as the only active ingredient to counteract signs of skin aging. Preliminary study approved the formula in terms of appearance, odor and volume, within the product considered cosmetic and was determined pH of 5.67 and density of 1.0483g / ml. A skin cream with FCE Oligopeptide-1, white viscose, free of lumps, was then made with Polybase CT-20%; Octyl Palmitate - 5%; Softisan 649-5%; Glycerin - 2%; Cetiol 868-2%; Edta - 0.2%; Henoxetol -1%; BHT - 0.05%; Flower Essence of Plum - 1%; Nano Water osmosis qsp - 60ml and FCE - 3%. Physical-chemical, organoleptic and microbiological stability tests were appropriated and approved. Conclusion: A skin cream with FCE oligopéptido-1 has been developed.