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    Alterações da VE/VCO2 e OUES durante exercício progressivo máximo em pacientes com insuficiência cardíaca
    (Universidade Federal de São Paulo (UNIFESP), 2019-12-06) Aguillar, Iago Nunes [UNIFESP]; Medeiros, Alessandra [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Heart failure is a complex clinical syndrome that originated from various etiologies resulting in cardiorespiratory impairment during physical exertion. Objective: To compare the behavior of cardiorespiratory variables, inclination of oxygen absorption efficiency (OUES) and the relationship between pulmonary ventilation and carbon dioxide production (VE/VCO2 ) between heart failure and healthy individuals. Methods: A total of 61 male subjects (61.2 ± 7,8 years) were separated into two groups: Patients with heart failure (n = 40) and Control Group (n = 21), All patients underwent assessments of the following anthropometric parameters: age, height, body mass and body mass index. The ergospirometric test was also performed, which consisted of performing a treadmill exercise with direct respiratory gas analysis: VE/VCO2, VO2peak, PetCO2, OUES and hemodynamic variables: Maximum heart rate, Recovery heart rate after 1 Minute and echocardiography for ejection fraction a nalysis. The Kolmorovsminoff test was performed for normality, the data were expressed as mean and standard error, and the inferential analysis was performed with the Anova Tests and Post-Hoc Scheffé Test, considering p≤0.05. Results: The anthropometric, hemodynamic and respiratory variables results for group IC and C are: age = 61.0±8.2 vs. 61.5±7.4 years (p>0.05), Height = 1.72±5.8 vs. 1.72±6.8m (p>0.05), body mass = 77.3±9.9 vs. 78.3±9.0kg (p>0.05), body mass index = 26.5±3.0 vs. 26.2±2.8 kg/m2 (p>0.05), ejection fraction = 31.2±4.1 vs. 64.7±3.9mL (p <0.001), maximum heart rate = 128.6±22.9 vs. 143.6±15.5bpm (p <0.02), recovery heart rate after the first minute = - 17.4±5.4 vs. -25.0±4.9bpm (p <0.05), VE/VCO2slope = 38.8±5.6 vs. 28.2±3.9L/min (p <0.003), VO2peak = 20.0±4.0 vs. 36.7±5.5ml/kg/min (p <0.05), PetCO2 = 29.5±3.0 vs. 31.7±2.4mmHg (p <0.05) and OUES = 1.81±0.4 vs. 2.3±0.3 (p <0.05). Conclusion: Heart failure patients present high VE/VCO2 and low OUES values which limits the functional capacity and causes early onset of metabolic acidosis.